Literature summary for 3.1.3.46 extracted from

Wu, C.; Okar, D.A.; Stoeckman, A.K.; Peng, L.J.; Herrera, A.H.; Herrera, J.E.; Towle, H.C.; Lange, A.J.
A potential role for fructose-2,6-bisphosphate in the stimulation of hepatic glucokinase gene expression (2004), Endocrinology, 145, 650-658.

Search for more literature for 3.1.3.46

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	insulin highly induces the enzyme expression	Mus musculus

Cloned(Commentary)

Cloned (Comment)	Organism
overexpression of hepatic 6-phosphofructo-2-kinase/fructose-2,6-bisphosphate using an adenoviral vector	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	streptozotocin highly reduces enzyme expression, treated mice show undetecable low levels of insulin, the effect is reversible by application of insulin	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Mus musculus	enzyme expression is highly reduced in diabetic mice, insulin is required for enzyme induction/regulation, a high enzyme expression level reduces blood glucose level and increases the expression of glucokinase, metabolic regulation overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	male 129J mice	-

Purification (Commentary)

Purification (Comment)	Organism
partially from liver	Mus musculus

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	enzyme expression level determination	Mus musculus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	-	Mus musculus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	enzyme expression is highly reduced in diabetic mice, insulin is required for enzyme induction/regulation, a high enzyme expression level reduces blood glucose level and increases the expression of glucokinase, metabolic regulation overview	Mus musculus	?	-	?

Synonyms

Synonyms	Comment	Organism
6-phosphofructo-2-kinase/fructose-2,6-bisphosphate	-	Mus musculus
F-2,6-P2	-	Mus musculus
More	cf. EC 2.7.1.105	Mus musculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)