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Literature summary for 3.1.3.46 extracted from

  • Perez, J.X.; Roig, T.; Manzano, A.; Dalmau, M.; Boada, J.; Ventura, F.; Rosa, J.L.; Bermudez, J.; Bartrons, R.
    Overexpression of fructose 2,6-bisphosphatase decreases glycolysis and delays cell cycle progression (2000), Am. J. Physiol., 279, C1359-1365.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information overexpression of intact enzyme results in small increase of kinase activity and levels of fructose-1,6-bisphosphate with little effects on cell metabolism, overexpression of bisphosphatase domain results in signifikant decrease in fructose-1,6-bisphosphatase concentration as well as decrease in lactate production and ATP concentration Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus enzyme involved in regulation of glycolytic flux, role of glycolysis in cell cycle progression ?
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?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, recombinant enzyme expressed in Mv1Lu cells
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Source Tissue

Source Tissue Comment Organism Textmining
liver
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Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme involved in regulation of glycolytic flux, role of glycolysis in cell cycle progression Rattus norvegicus ?
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?