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Literature summary for 3.1.3.43 extracted from

  • McLean, P.; Kunjara, S.; Greenbaum, A.L.; Gumaa, K.; Lopez-Prados, J.; Martin-Lomas, M.; Rademacher, T.W.
    Reciprocal control of pyruvate dehydrogenase kinase and phosphatase by inositol phosphoglycans. Dynamic state set by "push-pull" system (2008), J. Biol. Chem., 283, 33428-33436.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.43

Activating Compound

Activating Compound Comment Organism Structure
inositol phosphoglycan P-type linear stimulation Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
Zn2+ about 20% decrease of activity in the presence of 0.01 mM Zn2+; about 20% decrease of activity in the presence of 0.01 mM Zn2+ Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Bos taurus 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ the addition of 0.1 mM Ca2+ alone gives a 6fold increase in basal PDP activity Bos taurus
Mn2+ about 50% stimulation of activity in the presence of 1 mM Mn2+ Bos taurus
Zn2+ about 70% stimulation of activity in the presence of 0.01 mM Zn2+ Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Bos taurus P35816
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[pyruvate dehydrogenase (lipoamide)]-phosphate + H2O
-
 Bos taurus [pyruvate dehydrogenase (lipoamide)] + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PDP1
-
 Bos taurus
PDP2
-
 Bos taurus
pyruvate dehydrogenase phosphatase type 1
-
 Bos taurus
pyruvate dehydrogenase phosphatase type 2
-
 Bos taurus