Literature summary for 3.1.3.43 extracted from

Leblanc, P.J.; Mulligan, M.; Antolic, A.; Macpherson, L.; Inglis, J.G.; Martin, D.; Roy, B.D.; Peters, S.J.
Skeletal muscle type comparison of pyruvate dehydrogenase phosphatase activity and isoform expression: effects of obesity and endurance training (2008), Am. J. Physiol. Regul. Integr. Comp. Physiol., 295, R1224-R1230.

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Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	obesity results in a 46% decrease in PDP activity while PDP isoform content is unchanged, 8 weeks of endurance training lead to a significant 1.4-2.2fold increase in isoform PDP1 activity of all muscle examined from obese rats; obesity results in a 46% decrease in PDP activity while PDP isoform content is unchanged, isoform PDP2 protein content is not affected by obesity or training	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Rattus norvegicus	5739	-

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	O88483	-	-
Rattus norvegicus	O88484	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
heart	-	Rattus norvegicus	-
kidney	-	Rattus norvegicus	-
skeletal muscle	-	Rattus norvegicus	-
skeletal muscle	PDP1 is the predominant isoform expressed in skeletal muscle	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
PDH phosphatase	-	Rattus norvegicus
PDP1	isoform	Rattus norvegicus
PDP2	isoform	Rattus norvegicus
pyruvate dehydrogenase phosphatase	-	Rattus norvegicus

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Release 2023.1 (January 2023)