Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | activation, overview | Mammalia | |
Mg2+ | two molecules per active site of each isoform, regulation of enzyme activity via effector-altered sensitivities to Mg2+-level | Mammalia |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mammalia | - |
two isoforms | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
[pyruvate dehydrogenase (acetyl-transferring)] phosphate + H2O = [pyruvate dehydrogenase (acetyl-transferring)] + phosphate | overview on mechanism and regulation of enzyme | Mammalia |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipose tissue | PDP2, probably target for insulin activation | Mammalia | - |
brain | PDP1 | Mammalia | - |
heart | PDP1 | Mammalia | - |
kidney | PDP1 | Mammalia | - |
liver | PDP1, PDP2 | Mammalia | - |
skeletal muscle | PDP1 | Mammalia | - |
Subunits | Comment | Organism |
---|---|---|
heterodimer | isoform PDP1, composed of catalytic subunit PDP1c and regulatory subunit PDP1r of 96000 Da, overview | Mammalia |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | noncovalently bound to PDP1r | Mammalia |