Literature summary for 3.1.3.4 extracted from

Pascual, F.; Soto-Cardalda, A.; Carman, G.M.
PAH1-encoded phosphatidate phosphatase plays a role in the growth phase- and inositol-mediated regulation of lipid synthesis in Saccharomyces cerevisiae (2013), J. Biol. Chem., 288, 35781-35792.

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Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	P32567	-	-

Expression

Organism	Comment	Expression
Saccharomyces cerevisiae	expression is induced throughout growth and the induction in the stationary phase is stimulated by inositol supplementation. The Ino2p/Ino4p/Opi1p regulatory circuit and transcription factors Gis1p and Rph1p mediated this regulation	up

General Information

General Information	Comment	Organism
physiological function	isoform Pah1p regulates lipid synthesis and composition throughout growth. An enzyme deletion mutant shows dramatic reductions in the synthesis of triacylglycerols and diacylglycerols and increases in synthesis of phospholipids, fatty acids, and ergosterol esters when compared with the wild type control. Pahip is dephosphorylated by the Nem1p-Spo7p protein phosphatase complex. Nem1 deletion mutant cells exhibit defects in triacylglycerol synthesis and lipid metabolism that mirror those imparted by the Pah1 deletion mutation	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)