Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.3.4 extracted from

  • Fakas, S.; Qiu, Y.; Dixon, J.L.; Han, G.S.; Ruggles, K.V.; Garbarino, J.; Sturley, S.L.; Carman, G.M.
    Phosphatidate phosphatase activity plays key role in protection against fatty acid-induced toxicity in yeast (2011), J. Biol. Chem., 286, 29074-29085.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.4

Protein Variants

Protein Variants Comment Organism
D398E inactive Saccharomyces cerevisiae
D400E inactive Saccharomyces cerevisiae
G80R inactive Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
EDTA complete inhibition at 2 mM Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Saccharomyces cerevisiae 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ dependent on Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-
Saccharomyces cerevisiae W303-1A
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphatidic acid + H2O
-
 Saccharomyces cerevisiae 1,2-diacyl-sn-glycerol + phosphate
-
 ?
phosphatidic acid + H2O
-
 Saccharomyces cerevisiae W303-1A 1,2-diacyl-sn-glycerol + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PA phosphatase
-
 Saccharomyces cerevisiae
PAP
-
 Saccharomyces cerevisiae

Expression

Organism Comment Expression
Saccharomyces cerevisiae wild type cells supplemented with palmitoleic acid exhibit an induction in phosphatidate phosphatase activity up

General Information

General Information Comment Organism
malfunction cells lacking phosphatidate phosphatase are sensitive to exogenous fatty acids in the order of toxicity palmitoleic acid > oleic acid > palmitic acid Saccharomyces cerevisiae
physiological function phosphatidate phosphatase activity is essential in protecting cells from palmitoleic acid (fatty acid)-induced toxicity Saccharomyces cerevisiae