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Literature summary for 3.1.3.4 extracted from
- Insulin-stimulated interaction with 14-3-3 promotes cytoplasmic localization of lipin-1 in adipocytes (2010), J. Biol. Chem., 285, 3857-3864.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| HEK293 cells or 3T3-L1 adipocytes transfected with wild-type or mutant lipin-1alpha lacking the serine-rich domain | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | mutant lipin-1alpha lacking the serine-rich domain, is excluded from the nucleus | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| additional information | 20% of transfected 3T3-L1 adipocyte cells contain lipin-1alpha exclusively in the nucleus, in more than 50% of cells lipin-1alpha is present in similar amounts in the cytoplasm and the nucleus. 14-3-3 proteins promote cytoplasmic localization of lipin-1alpha | Mus musculus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| lipin-1alpha | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | endogenous 14-3-3 proteins interact with lipin-1alpha in HEK293 cells, overexpression of 14-3-3 promotes the cytoplasmic localization of lipin-1 in 3T3-L1 adipocytes. Effect of 14-3-3 is mediated through a serine-rich domain in lipin-1. Insulin stimulates interaction with 14-3-3 and cytoplasmic localization of lipin-1alpha in 3T3-L1 adipocytes | Mus musculus |
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Release 2023.1 (January 2023)
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