Protein Variants | Comment | Organism |
---|---|---|
additional information | pah1? mutants show a temperature sensitivity phenotype | Saccharomyces cerevisiae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
bromoenol lactone | selective inhibition of PAP1 | Saccharomyces cerevisiae | |
diacylglycerol | DPP1-encoded PAP2 enzyme is inhibited by CDP-DAG | Saccharomyces cerevisiae | |
NEM | the yeast DPP1-encoded PAP2 activity is insensitive to NEM, whereas LPP1-encoded PAP2 activity is sensitive to NEM | Saccharomyces cerevisiae | |
Zn2+ | PAP2 activity is also inhibited by Zn2+ ions in a mechanism that involves the formation of DGPP-Zn2+ complexes | Saccharomyces cerevisiae |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | isozyme PAP1 | Saccharomyces cerevisiae | 5829 | - |
membrane | isozyme PAP1, PAP2s are integral membrane proteins | Saccharomyces cerevisiae | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | Lpp1p contains ten cysteine residues, whereas Dpp1p and Pah1p contain only three | Saccharomyces cerevisiae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidic acid + H2O | Saccharomyces cerevisiae | PAP activity has a central role in the synthesis of phospholipids and triacylglycerol through its product diacylglycerol, and it also generates and/or degrades lipid-signaling molecules that are related to phosphatidate, isozyme PAP1 plays a role in the transcriptional regulation of phospholipid synthesis, overview | 1,2-diacylglycerol + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
isozymes PAP1 and PAP2, encoded by genes PAH1, formerly known as SMP2, and DPP1 and LPP1, respectively | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidic acid + H2O | - |
Saccharomyces cerevisiae | 1,2-diacylglycerol + phosphate | - |
? | |
phosphatidic acid + H2O | PAP activity has a central role in the synthesis of phospholipids and triacylglycerol through its product diacylglycerol, and it also generates and/or degrades lipid-signaling molecules that are related to phosphatidate, isozyme PAP1 plays a role in the transcriptional regulation of phospholipid synthesis, overview | Saccharomyces cerevisiae | 1,2-diacylglycerol + phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | PAP1 enzyme has a DxDxT catalytic motif within a haloacid dehalogenase- like domain, the DPP1-and LPP1-encoded PAP2 enzymes contain a three-domain lipid phosphatase motif that is localized to the hydrophilic surface of the membrane | Saccharomyces cerevisiae |
Synonyms | Comment | Organism |
---|---|---|
3-sn-phosphatidate phosphohydrolase | - |
Saccharomyces cerevisiae |
Dpp1p | - |
Saccharomyces cerevisiae |
Lpp1p | - |
Saccharomyces cerevisiae |
Pah1p | - |
Saccharomyces cerevisiae |
PAP1 | - |
Saccharomyces cerevisiae |
PAP2 | - |
Saccharomyces cerevisiae |