Application | Comment | Organism |
---|---|---|
additional information | LPP1 overexpression markedly reduces platelet-derived growth factor-induced activation of p42/p44 mitogen-activated protein kinase. This occurs via a mechanism that involves the LPP1-induced down-regulation of typical protein kinase C isoform(s), which are normally required for platelet-derived growth factor-induced activation of p42/p44 mitogen-activated protein kinase and migration | Mus musculus |
Cloned (Comment) | Organism |
---|---|
overexpression in HEK-293 cells | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | LPP-1 overexpression mutant shows inhibited cell migration of embryonic fibroblasts by reduction of lysophosphatidic acid- and platelet-derived-growth-factor-induced activation of the p42/p44 MAPK pathway, overview | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | integral | Mus musculus | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
lysophosphatidic acid + H2O | Mus musculus | - |
monoacylglycerol + phosphate | - |
? | |
additional information | Mus musculus | LPP is involved in regulation of bioactive lipids acting in signalling pathways, LPP-1 regulates lysophosphatidic acid- and platelet-derived-growth-factor-induced cell migration via the p42/p44 MAPK pathway, overview | ? | - |
? | |
sphingosine 1-phosphate + H2O | Mus musculus | - |
sphingosine + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Mus musculus | - |
isozyme LPP-1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | - |
Mus musculus | - |
fibroblast | embryonic, derived from LPP-1 overexpression mutant and wild-type mice | Mus musculus | - |
MEF cell | - |
Mus musculus | - |
MEF cell | embryonic fibroblast cell line | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glycerophosphate + H2O | - |
Mus musculus | glycerol + phosphate | - |
? | |
lysophosphatidic acid + H2O | - |
Mus musculus | monoacylglycerol + phosphate | - |
? | |
additional information | LPP is involved in regulation of bioactive lipids acting in signalling pathways, LPP-1 regulates lysophosphatidic acid- and platelet-derived-growth-factor-induced cell migration via the p42/p44 MAPK pathway, overview | Mus musculus | ? | - |
? | |
sphingosine 1-phosphate + H2O | - |
Mus musculus | sphingosine + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
lipid phosphate phosphatase | - |
Mus musculus |
lipid phosphate phosphatase-1 | - |
Mus musculus |
LPP | - |
Mus musculus |
LPP1 | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | - |
assay at | Mus musculus |