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Literature summary for 3.1.3.4 extracted from

  • Long, J.S.; Yokoyama, K.; Tigyi, G.; Pyne, N.J.; Pyne, S.
    Lipid phosphate phosphatase-1 regulates lysophosphatidic acid- and platelet-derived-growth-factor-induced cell migration (2006), Biochem. J., 394, 495-500.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
additional information LPP1 overexpression markedly reduces platelet-derived growth factor-induced activation of p42/p44 mitogen-activated protein kinase. This occurs via a mechanism that involves the LPP1-induced down-regulation of typical protein kinase C isoform(s), which are normally required for platelet-derived growth factor-induced activation of p42/p44 mitogen-activated protein kinase and migration Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in HEK-293 cells Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information LPP-1 overexpression mutant shows inhibited cell migration of embryonic fibroblasts by reduction of lysophosphatidic acid- and platelet-derived-growth-factor-induced activation of the p42/p44 MAPK pathway, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane integral Mus musculus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
lysophosphatidic acid + H2O Mus musculus
-
monoacylglycerol + phosphate
-
?
additional information Mus musculus LPP is involved in regulation of bioactive lipids acting in signalling pathways, LPP-1 regulates lysophosphatidic acid- and platelet-derived-growth-factor-induced cell migration via the p42/p44 MAPK pathway, overview ?
-
?
sphingosine 1-phosphate + H2O Mus musculus
-
sphingosine + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus
-
isozyme LPP-1
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
Mus musculus
-
fibroblast embryonic, derived from LPP-1 overexpression mutant and wild-type mice Mus musculus
-
MEF cell
-
Mus musculus
-
MEF cell embryonic fibroblast cell line Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glycerophosphate + H2O
-
Mus musculus glycerol + phosphate
-
?
lysophosphatidic acid + H2O
-
Mus musculus monoacylglycerol + phosphate
-
?
additional information LPP is involved in regulation of bioactive lipids acting in signalling pathways, LPP-1 regulates lysophosphatidic acid- and platelet-derived-growth-factor-induced cell migration via the p42/p44 MAPK pathway, overview Mus musculus ?
-
?
sphingosine 1-phosphate + H2O
-
Mus musculus sphingosine + phosphate
-
?

Synonyms

Synonyms Comment Organism
lipid phosphate phosphatase
-
Mus musculus
lipid phosphate phosphatase-1
-
Mus musculus
LPP
-
Mus musculus
LPP1
-
Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
assay at Mus musculus