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Literature summary for 3.1.3.4 extracted from

  • Bowley, M.; Cooling, J.; Burditt, S.L.; Brindley, D.N.
    The effects of amphiphilic cationic drugs and inorganic cations on the activity of phosphatidate phosphohydrolase (1977), Biochem. J., 165, 447-454.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
chlorpromazine stimulates in absence of added Mg2+ Rattus norvegicus
spermidine stimulates Rattus norvegicus
spermine stimulates Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
Ca2+ inhibition at optimal concentrations of Mg2+ Rattus norvegicus
chlorpromazine competitive inhibition at optimal concentrations of Mg2+ Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ stimulates Rattus norvegicus
Co2+ stimulates Rattus norvegicus
Fe2+ stimulates Rattus norvegicus
Fe3+ stimulates Rattus norvegicus
Mg2+ required Rattus norvegicus
Mn2+
-
Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphatidic acid + H2O
-
Rattus norvegicus 1,2-diacyl-sn-glycerol + phosphate
-
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