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Literature summary for 3.1.3.4 extracted from

  • Casola, P.G.; Possmayer, F.
    Separation and characterization of the membrane-bound and aqueously dispersed phosphatidate phosphatidic acid phosphohydrolase activities in rat lung (1981), Biochim. Biophys. Acta, 664, 298-315.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Triton X-100 5.5fold increase in activity with membrane-bound phosphatidic acid Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
EDTA inhibits activity with membrane-bound phosphatidic acid in the cytosol by 65%, the activity with aqueously dispersed phosphatidic acid is inhibited 10% Rattus norvegicus
Triton X-100 slight depression of activity with aqueously dispersed phosphatidic acid Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Rattus norvegicus 5829
-
microsome
-
Rattus norvegicus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ MgCl2 stimulates activity with membrane-bound phosphatidic acid in the cytosol by 7%, the activity with aqueously dispersed phosphatidic acid is inhibited 80% Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphatidic acid + H2O membrane-bound phosphatidic acid and aqueously dispersed phosphatidic acid Rattus norvegicus 1,2-diacyl-sn-glycerol + phosphate
-
?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
55
-
20 min, 70% loss of activity with membrane-bound phosphatidic acid, 24% loss of activity with aqueously dispersed phosphatidic acid Rattus norvegicus