Literature summary for 3.1.3.25 extracted from

Naccarato, W.F.; Ray, R.E.; Wells, W.W.
Biosynthesis of myo-inositol in rat mammary gland. Isolation and properties of the enzymes (1974), Arch. Biochem. Biophys., 164, 194-201.

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Activating Compound

Activating Compound	Comment	Organism	Structure
NH4+	stimulatory	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
KF	-	Rattus norvegicus
Li+	-	Rattus norvegicus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.8	-	L-myo-Inositol 1-phosphate	-	Rattus norvegicus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Co2+	-	Rattus norvegicus
K+	-	Rattus norvegicus
Mg2+	-	Rattus norvegicus
Mn2+	stimulates	Rattus norvegicus
Mn2+	gave 17% of the acitivity provided with Mg2+	Rattus norvegicus
Na+	-	Rattus norvegicus
NH4+	stimulatory	Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
52000	-	4 * 52000, gel filtration after heating	Rattus norvegicus
210000	-	gel filtration	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
partial	Rattus norvegicus

Source Tissue

Source Tissue	Comment	Organism	Textmining
mammary gland	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-glycerol 1-phosphate + H2O	-	Rattus norvegicus	glycerol + phosphate	-	?
L-myo-inositol 1-phosphate + H2O	-	Rattus norvegicus	L-myo-inositol + phosphate	-	?
additional information	-	Rattus norvegicus	?	-	?

Subunits

Subunits	Comment	Organism
tetramer	4 * 52000, gel filtration after heating	Rattus norvegicus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
8	-	-	Rattus norvegicus

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Release 2023.1 (January 2023)