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Literature summary for 3.1.3.25 extracted from
- Purification and properties of myo-inositol-1-phosphatase from rat brain (1985), J. Biochem., 98, 363-370.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | strong competitive against Mg2+ | Rattus norvegicus |  |
| Cu2+ | - |
Rattus norvegicus | |
| Li+ | inhibits 50% of activity at 1 mM, uncompetitive inhibitor | Rattus norvegicus | |
| Mn2+ | strong competitive against Mg2+ | Rattus norvegicus | |
| NaF | inhibits by 60% and 100% at 1 mM and 5 mM respectively | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.12 | - |
DL-myo-inositol 1-phosphate | - |
Rattus norvegicus | |
| 0.19 | - |
2'-AMP | - |
Rattus norvegicus | |
| 0.77 | - |
Glycerol 2-phosphate | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Rattus norvegicus | 5737 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | 40% stimulation | Rattus norvegicus | |
| Co2+ | less effective than Mg2+, cannot substitute for Mg2+ | Rattus norvegicus | |
| Fe2+ | less effective than Mg2+, cannot substitute for Mg2+ | Rattus norvegicus | |
| Mg2+ | stimulates | Rattus norvegicus | |
| Mn2+ | stimulates slightly | Rattus norvegicus | |
| Zn2+ | 40% stimulation | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 29000 | - |
2 * 29000, SDS-PAGE | Rattus norvegicus |
| 55000 | - |
gel filtration | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| myo-inositol 1-phosphate + H2O | Rattus norvegicus | - |
myo-inositol + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| 6000 and 2563fold | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.85 | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2'-AMP + H2O | - |
Rattus norvegicus | adenosine + phosphate | - |
? | |
| 2'-GMP + H2O | - |
Rattus norvegicus | guanosine + phosphate | - |
? | |
| DL-myo-inositol 1-phosphate + H2O | - |
Rattus norvegicus | DL-myo-inositol + phosphate | - |
? | |
| glycerol 2-phosphate + H2O | - |
Rattus norvegicus | glycerol + phosphate | - |
? | |
| L-glycerol 1-phosphate + H2O | - |
Rattus norvegicus | glycerol + phosphate | - |
? | |
| additional information | - |
Rattus norvegicus | ? | - |
? | |
| myo-inositol 1-phosphate + H2O | - |
Rattus norvegicus | myo-inositol + phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 29000, SDS-PAGE | Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
- |
Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
for L-myo-inositol-1-phosphate | Rattus norvegicus |
| 8 | - |
for 2-AMP, beta-glycerophosphate | Rattus norvegicus |
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