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Literature summary for 3.1.3.2 extracted from

  • Sowa, N.A.; Street, S.E.; Vihko, P.; Zylka, M.J.
    Prostatic acid phosphatase reduces thermal sensitivity and chronic pain sensitization by depleting phosphatidylinositol 4,5-bisphosphate (2010), J. Neurosci., 30, 10282-10293.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Synonyms

Synonyms Comment Organism
acid phosphatase
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Homo sapiens
PAP
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Homo sapiens

General Information

General Information Comment Organism
physiological function in mice, intrathecal injection of human PAP reduces PIP2 levels in dorsal root ganglionss, inhibits thermosensation through TRPV1, and enduringly reduces thermal hyperalgesia and mechanical allodynia caused by inflammation, nerve injury, and pronociceptive receptor activation. This includes inhibitory effects on lysophosphatidic acid, purinergic (ATP), bradykinin, and protease-activated (thrombin) receptors Homo sapiens