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Literature summary for 3.1.3.11 extracted from

  • Dai, J.; Finci, L.; Zhang, C.; Lahiri, S.; Zhang, G.; Peisach, E.; Allen, K.N.; Dunaway-Mariano, D.
    Analysis of the structural determinants underlying discrimination between substrate and solvent in beta-phosphoglucomutase catalysis (2009), Biochemistry, 48, 1984-1995.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
-
Neisseria meningitidis
-
Lactobacillus delbrueckii subsp. lactis

Crystallization (Commentary)

Crystallization (Comment) Organism
T16P mutant, hanging drop vapor diffusion method, using 25% (w/v) PEG, 0.2 M NaCl, and 100 mM bis-Tris (pH 6.0) Lactobacillus delbrueckii subsp. lactis

Protein Variants

Protein Variants Comment Organism
D10A inactive Neisseria meningitidis
D10C inactive Lactobacillus delbrueckii subsp. lactis
D10E inactive Neisseria meningitidis
D10N inactive Lactobacillus delbrueckii subsp. lactis
D10S inactive Lactobacillus delbrueckii subsp. lactis
H20A the mutant shows reduced activity compared to the wild type enzyme Lactobacillus delbrueckii subsp. lactis
H20N the mutant shows reduced activity compared to the wild type enzyme Lactobacillus delbrueckii subsp. lactis
H20Q the mutant shows reduced activity compared to the wild type enzyme Lactobacillus delbrueckii subsp. lactis
K76A the mutant shows reduced activity compared to the wild type enzyme Lactobacillus delbrueckii subsp. lactis
T16P the mutant shows reduced activity compared to the wild type enzyme Lactobacillus delbrueckii subsp. lactis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0026
-
beta-D-glucose 1,6-bisphosphate wild type enzyme, in 50 mM K+HEPES pH 7.0 at 25°C Neisseria meningitidis
0.0048
-
beta-D-glucose 1,6-bisphosphate mutant enzyme T16P, in 50 mM K+HEPES pH 7.0 at 25°C Lactobacillus delbrueckii subsp. lactis
0.031
-
beta-D-glucose 1,6-bisphosphate wild type enzyme, in 50 mM K+HEPES pH 7.0 at 25°C Lactobacillus delbrueckii subsp. lactis
0.041
-
beta-D-glucose 1,6-bisphosphate mutant enzyme H20A, in 50 mM K+HEPES pH 7.0 at 25°C Lactobacillus delbrueckii subsp. lactis
0.045
-
beta-D-glucose 1,6-bisphosphate mutant enzyme H20Q, in 50 mM K+HEPES pH 7.0 at 25°C Lactobacillus delbrueckii subsp. lactis
0.066
-
beta-D-glucose 1,6-bisphosphate mutant enzyme K76A, in 50 mM K+HEPES pH 7.0 at 25°C Lactobacillus delbrueckii subsp. lactis
0.17
-
beta-D-glucose 1,6-bisphosphate mutant enzyme H20N, in 50 mM K+HEPES pH 7.0 at 25°C Lactobacillus delbrueckii subsp. lactis

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Neisseria meningitidis
Mg2+ required Lactobacillus delbrueckii subsp. lactis

Organism

Organism UniProt Comment Textmining
Lactobacillus delbrueckii subsp. lactis
-
-
-
Neisseria meningitidis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Neisseria meningitidis
-
Lactobacillus delbrueckii subsp. lactis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-D-glucose 1,6-bisphosphate + H2O
-
Neisseria meningitidis D-glucose 6-phosphate + phosphate
-
?
beta-D-glucose 1,6-bisphosphate + H2O
-
Lactobacillus delbrueckii subsp. lactis D-glucose 6-phosphate + phosphate
-
?

Synonyms

Synonyms Comment Organism
beta-PGM
-
Neisseria meningitidis
beta-PGM
-
Lactobacillus delbrueckii subsp. lactis

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.026
-
beta-D-glucose 1,6-bisphosphate mutant enzyme H20A, in 50 mM K+HEPES pH 7.0 at 25°C Lactobacillus delbrueckii subsp. lactis
0.026
-
beta-D-glucose 1,6-bisphosphate mutant enzyme T16P, in 50 mM K+HEPES pH 7.0 at 25°C Lactobacillus delbrueckii subsp. lactis
0.62
-
beta-D-glucose 1,6-bisphosphate mutant enzyme H20N, in 50 mM K+HEPES pH 7.0 at 25°C Lactobacillus delbrueckii subsp. lactis
1.56
-
beta-D-glucose 1,6-bisphosphate mutant enzyme K76A, in 50 mM K+HEPES pH 7.0 at 25°C Lactobacillus delbrueckii subsp. lactis
20
-
beta-D-glucose 1,6-bisphosphate wild type enzyme, in 50 mM K+HEPES pH 7.0 at 25°C Neisseria meningitidis
21.9
-
beta-D-glucose 1,6-bisphosphate mutant enzyme H20Q, in 50 mM K+HEPES pH 7.0 at 25°C Lactobacillus delbrueckii subsp. lactis
175
-
beta-D-glucose 1,6-bisphosphate wild type enzyme, in 50 mM K+HEPES pH 7.0 at 25°C Lactobacillus delbrueckii subsp. lactis

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.6
-
beta-D-glucose 1,6-bisphosphate mutant enzyme H20A, in 50 mM K+HEPES pH 7.0 at 25°C Lactobacillus delbrueckii subsp. lactis
4
-
beta-D-glucose 1,6-bisphosphate mutant enzyme H20N, in 50 mM K+HEPES pH 7.0 at 25°C Lactobacillus delbrueckii subsp. lactis
5
-
beta-D-glucose 1,6-bisphosphate mutant enzyme T16P, in 50 mM K+HEPES pH 7.0 at 25°C Lactobacillus delbrueckii subsp. lactis
20
-
beta-D-glucose 1,6-bisphosphate mutant enzyme K76A, in 50 mM K+HEPES pH 7.0 at 25°C Lactobacillus delbrueckii subsp. lactis
500
-
beta-D-glucose 1,6-bisphosphate mutant enzyme H20Q, in 50 mM K+HEPES pH 7.0 at 25°C Lactobacillus delbrueckii subsp. lactis
6000
-
beta-D-glucose 1,6-bisphosphate wild type enzyme, in 50 mM K+HEPES pH 7.0 at 25°C Lactobacillus delbrueckii subsp. lactis
8000
-
beta-D-glucose 1,6-bisphosphate wild type enzyme, in 50 mM K+HEPES pH 7.0 at 25°C Neisseria meningitidis