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Literature summary for 3.1.3.11 extracted from

  • Zarzycki, M.; Maciaszczyk, E.; Dzugaj, A.
    Glu 69 is essential for the high sensitivity of muscle fructose-1,6-bisphosphatase inhibition by calcium ions (2007), FEBS Lett., 581, 1347-1350.
    View publication on PubMed
Search for more literature for 3.1.3.11

Protein Variants

Protein Variants Comment Organism
E69Q mutation of E69Q results in a 500fold increase of muscle isozyme I0.5 versus Ca2+ Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
AMP
-
 Oryctolagus cuniculus
Ca2+ Glu 69 is essential for the high sensitivity of muscle fructose-1,6-bisphosphatase inhibition by calcium ions Oryctolagus cuniculus
D-fructose 2,6-bisphosphate
-
 Oryctolagus cuniculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0021
-
 D-fructose 1,6-bisphosphate native rabbit muscle FBPase Oryctolagus cuniculus
0.0031
-
 D-fructose 1,6-bisphosphate mutant E69Q of rabbit muscle FBPase Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
muscle
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-fructose 1,6-bisphosphate + H2O
-
 Oryctolagus cuniculus D-fructose 6-phosphate + phosphate
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00023
-
 D-fructose 2,6-bisphosphate native rabbit muscle FBPase Oryctolagus cuniculus
0.00035
-
 D-fructose 2,6-bisphosphate mutant E69Q of rabbit muscle FBPase Oryctolagus cuniculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00016
-
 native rabbit muscle FBPase Oryctolagus cuniculus AMP
0.00021
-
 mutant E69Q of rabbit muscle FBPase Oryctolagus cuniculus AMP
0.00074
-
 native rabbit muscle FBPase Oryctolagus cuniculus Ca2+