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Literature summary for 3.1.3.11 extracted from

  • Nishimasu, H.; Fushinobu, S.; Shoun, H.; Wakagi, T.
    The first crystal structure of the novel class of fructose-1,6-bisphosphatase present in thermophilic archaea (2004), Structure, 12, 949-959.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
structure contains an unhydrolized substrate molecule in open-keto form, and four hexacoordinated magnesium ions Sulfurisphaera tokodaii

Inhibitors

Inhibitors Comment Organism Structure
Mn2+ inhibitory above 3 mM Sulfurisphaera tokodaii
Zn2+ inhibitory above 3 mM Sulfurisphaera tokodaii

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ absolute requirement for divalent cation, fulfilled by Mg2+, Zn2+, Mn2+, maximum activity at 5 mM. Four molecules per homooctamer, crystallization data Sulfurisphaera tokodaii
Mn2+ absolute requirement for divalent cation, fulfilled by Mg2+, Zn2+, Mn2+, both Zn2+ and Mn2+ are inhibitory above 3 mM Sulfurisphaera tokodaii
Zn2+ absolute requirement for divalent cation, fulfilled by Mg2+, Zn2+, Mn2+, both Zn2+ and Mn2+ are inhibitory above 3 mM Sulfurisphaera tokodaii

Organism

Organism UniProt Comment Textmining
Sulfurisphaera tokodaii
-
-
-
Sulfurisphaera tokodaii 7
-
-
-

Subunits

Subunits Comment Organism
octamer crystallization data Sulfurisphaera tokodaii

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
100
-
and above, highly thermophilic enzyme Sulfurisphaera tokodaii

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
Sulfurisphaera tokodaii