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Literature summary for 3.1.3.11 extracted from

  • Naderer, T.; Ellis, M.A.; Sernee, M.F.; De Souza, D.P.; Curtis, J.; Handman, E.; McConville, M.J.
    Virulence of Leishmania major in macrophages and mice requires the gluconeogenic enzyme fructose-1,6-bisphosphatase (2006), Proc. Natl. Acad. Sci. USA, 103, 5502-5507.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information enzyme null-mutant, unable to grow in the absence of hexose, null mutant promastigotes are internalized by macrophages and differentiate into amastigotes but are unable to replicate in the macrophage phagolysosome. Mutant persists in mice but fails to generate normal lesions Leishmania major

Localization

Localization Comment Organism GeneOntology No. Textmining
glycosome of host cell Leishmania major 20015
-

Organism

Organism UniProt Comment Textmining
Leishmania major
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constituvie expression of enzyme in both extracellular and intracellular stages
-

Source Tissue

Source Tissue Comment Organism Textmining