Literature summary for 3.1.26.5 extracted from

Zou, H.; Lee, J.; Kilani, A.F.; Kim, K.; Trang, P.; Kim, J.; Liu, F.
Engineered RNase P ribozymes increase their cleavage activities and efficacies in inhibiting viral gene expression in cells by enhancing the rate of cleavage and binding of the target mRNA (2004), J. Biol. Chem., 279, 32063-32070.

Search for more literature for 3.1.26.5

Application

Application	Comment	Organism
medicine	RNase P ribozyme variant (with a point mutation at nucleotide 95 of RNaseP catalytic RNA G95U that increases the rate of cleavage, and another mutation at A200C that enhances substrate binding of the ribozyme) is highly effective in inhibiting herpes simplex virus 1 gene expression	Escherichia coli

Protein Variants

Protein Variants	Comment	Organism
additional information	variant with a point mutation at nucleotide 95 of RNaseP catalytic RNA G95U that increases the rate of cleavage, and another mutation at A200C that enhances substrate binding of the ribozyme	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

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Release 2023.1 (January 2023)