Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.26.5 extracted from

  • Jarrous, N.
    Human ribonuclease P: subunits, function, and intranuclear localization (2002), RNA, 8, 1-7.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.26.5

Cloned(Commentary)

Cloned (Comment) Organism
chromosomal localization of genes encoding the RNase P subunits Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
Cajal body contains protein subunits Rpp29 and Rpp38 Homo sapiens 15030
-
cytoplasm RNA subunit H1 Homo sapiens 5737
-
mitochondrion RNase P and RNase MRP Homo sapiens 5739
-
mitochondrion RNase P and RNase MRP Saccharomyces cerevisiae 5739
-
nucleolus RNase P, all subunits Homo sapiens 5730
-
nucleus nucleoplasm, RNase P, all subunits Homo sapiens 5634
-
nucleus RNase P Saccharomyces cerevisiae 5634
-
perinuclear space RNA subunit H1 Homo sapiens
-
-
ribosome RNase MRP Homo sapiens 5840
-
ribosome RNase MRP Saccharomyces cerevisiae 5840
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
14000
-
 1 * 115000, protein subunit Pop1, + 1 * 40000, protein subunit Rpp40, + 1 * 38000, protein subunit Rpp38, + 1 * 30000, protein subunit Rpp30 or Rpp1, + 1 * 29000, protein subunit Rpp29 or Pop4, + 1 * 25000, protein subunit Rpp25, + 1 * 21000, protein subunit Rpp21 or Rpr2, + 1 * 20000, protein subunit Rpp20 or Pop7 or Rpp2, + 1 * 14000, protein subunit Rpp14, + 1 * 105000, RNA subunit H1 Homo sapiens
20000
-
 1 * 115000, protein subunit Pop1, + 1 * 40000, protein subunit Rpp40, + 1 * 38000, protein subunit Rpp38, + 1 * 30000, protein subunit Rpp30 or Rpp1, + 1 * 29000, protein subunit Rpp29 or Pop4, + 1 * 25000, protein subunit Rpp25, + 1 * 21000, protein subunit Rpp21 or Rpr2, + 1 * 20000, protein subunit Rpp20 or Pop7 or Rpp2, + 1 * 14000, protein subunit Rpp14, + 1 * 105000, RNA subunit H1 Homo sapiens
21000
-
 1 * 115000, protein subunit Pop1, + 1 * 40000, protein subunit Rpp40, + 1 * 38000, protein subunit Rpp38, + 1 * 30000, protein subunit Rpp30 or Rpp1, + 1 * 29000, protein subunit Rpp29 or Pop4, + 1 * 25000, protein subunit Rpp25, + 1 * 21000, protein subunit Rpp21 or Rpr2, + 1 * 20000, protein subunit Rpp20 or Pop7 or Rpp2, + 1 * 14000, protein subunit Rpp14, + 1 * 105000, RNA subunit H1 Homo sapiens
25000
-
 1 * 115000, protein subunit Pop1, + 1 * 40000, protein subunit Rpp40, + 1 * 38000, protein subunit Rpp38, + 1 * 30000, protein subunit Rpp30 or Rpp1, + 1 * 29000, protein subunit Rpp29 or Pop4, + 1 * 25000, protein subunit Rpp25, + 1 * 21000, protein subunit Rpp21 or Rpr2, + 1 * 20000, protein subunit Rpp20 or Pop7 or Rpp2, + 1 * 14000, protein subunit Rpp14, + 1 * 105000, RNA subunit H1 Homo sapiens
29000
-
 1 * 115000, protein subunit Pop1, + 1 * 40000, protein subunit Rpp40, + 1 * 38000, protein subunit Rpp38, + 1 * 30000, protein subunit Rpp30 or Rpp1, + 1 * 29000, protein subunit Rpp29 or Pop4, + 1 * 25000, protein subunit Rpp25, + 1 * 21000, protein subunit Rpp21 or Rpr2, + 1 * 20000, protein subunit Rpp20 or Pop7 or Rpp2, + 1 * 14000, protein subunit Rpp14, + 1 * 105000, RNA subunit H1 Homo sapiens
30000
-
 1 * 115000, protein subunit Pop1, + 1 * 40000, protein subunit Rpp40, + 1 * 38000, protein subunit Rpp38, + 1 * 30000, protein subunit Rpp30 or Rpp1, + 1 * 29000, protein subunit Rpp29 or Pop4, + 1 * 25000, protein subunit Rpp25, + 1 * 21000, protein subunit Rpp21 or Rpr2, + 1 * 20000, protein subunit Rpp20 or Pop7 or Rpp2, + 1 * 14000, protein subunit Rpp14, + 1 * 105000, RNA subunit H1 Homo sapiens
38000
-
 1 * 115000, protein subunit Pop1, + 1 * 40000, protein subunit Rpp40, + 1 * 38000, protein subunit Rpp38, + 1 * 30000, protein subunit Rpp30 or Rpp1, + 1 * 29000, protein subunit Rpp29 or Pop4, + 1 * 25000, protein subunit Rpp25, + 1 * 21000, protein subunit Rpp21 or Rpr2, + 1 * 20000, protein subunit Rpp20 or Pop7 or Rpp2, + 1 * 14000, protein subunit Rpp14, + 1 * 105000, RNA subunit H1 Homo sapiens
40000
-
 1 * 115000, protein subunit Pop1, + 1 * 40000, protein subunit Rpp40, + 1 * 38000, protein subunit Rpp38, + 1 * 30000, protein subunit Rpp30 or Rpp1, + 1 * 29000, protein subunit Rpp29 or Pop4, + 1 * 25000, protein subunit Rpp25, + 1 * 21000, protein subunit Rpp21 or Rpr2, + 1 * 20000, protein subunit Rpp20 or Pop7 or Rpp2, + 1 * 14000, protein subunit Rpp14, + 1 * 105000, RNA subunit H1 Homo sapiens
105000
-
 1 * 115000, protein subunit Pop1, + 1 * 40000, protein subunit Rpp40, + 1 * 38000, protein subunit Rpp38, + 1 * 30000, protein subunit Rpp30 or Rpp1, + 1 * 29000, protein subunit Rpp29 or Pop4, + 1 * 25000, protein subunit Rpp25, + 1 * 21000, protein subunit Rpp21 or Rpr2, + 1 * 20000, protein subunit Rpp20 or Pop7 or Rpp2, + 1 * 14000, protein subunit Rpp14, + 1 * 105000, RNA subunit H1 Homo sapiens
115000
-
 1 * 115000, protein subunit Pop1, + 1 * 40000, protein subunit Rpp40, + 1 * 38000, protein subunit Rpp38, + 1 * 30000, protein subunit Rpp30 or Rpp1, + 1 * 29000, protein subunit Rpp29 or Pop4, + 1 * 25000, protein subunit Rpp25, + 1 * 21000, protein subunit Rpp21 or Rpr2, + 1 * 20000, protein subunit Rpp20 or Pop7 or Rpp2, + 1 * 14000, protein subunit Rpp14, + 1 * 105000, RNA subunit H1 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens biosynthesis and regulation of RNase P, transient interactions with several proteins in the cell, the protein subunits are conserved between RNase P and RNase MRP, and are essential for cell viability and enzyme function, overview, enzyme subunits in nucleolus and Cajal bodies might be involved in cell mitosis and cell-cycle-dependent gene transcription ?
-
 ?
additional information Saccharomyces cerevisiae transient interactions with several proteins in the cell, e.g. protein subunit Rpp20 interacts with the heat shock protein Hsp27, protein subunit Rpp14 interacts with several proteins including the LIM domain protein 1 LIMD1 and the SR-rich HSPC232 ?
-
 ?
tRNA precursor + H2O Homo sapiens tRNA processing mature tRNA + 5'-oligonucleotide
-
 ?
tRNA precursor + H2O Saccharomyces cerevisiae tRNA processing, the premature substrate is associated with a complex of 7 Sm-like proteins, i.e. Lsm2-8, and U6 snRNA mature tRNA + 5'-oligonucleotide
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
RNase P from nucleus Saccharomyces cerevisiae

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information biosynthesis and regulation of RNase P, transient interactions with several proteins in the cell, the protein subunits are conserved between RNase P and RNase MRP, and are essential for cell viability and enzyme function, overview, enzyme subunits in nucleolus and Cajal bodies might be involved in cell mitosis and cell-cycle-dependent gene transcription Homo sapiens ?
-
 ?
additional information transient interactions with several proteins in the cell, e.g. protein subunit Rpp20 interacts with the heat shock protein Hsp27, protein subunit Rpp14 interacts with several proteins including the LIM domain protein 1 LIMD1 and the SR-rich HSPC232 Saccharomyces cerevisiae ?
-
 ?
additional information protein subunit Rpp20 also acts as an ATPase, protein subunits Rpp14, Rpp21, and Rpp29 are responsible for pre-tRNA substrate binding Homo sapiens ?
-
 ?
tRNA precursor + H2O tRNA processing Homo sapiens mature tRNA + 5'-oligonucleotide
-
 ?
tRNA precursor + H2O tRNA processing, the premature substrate is associated with a complex of 7 Sm-like proteins, i.e. Lsm2-8, and U6 snRNA Saccharomyces cerevisiae mature tRNA + 5'-oligonucleotide
-
 ?
tRNA precursor + H2O cleavage of 5'-terminal oligonucleotide Homo sapiens mature tRNA + 5'-oligonucleotide generates 5'-phosphate,3'-hydroxyl-product ?
tRNA precursor + H2O cleavage of 5'-terminal oligonucleotide Saccharomyces cerevisiae mature tRNA + 5'-oligonucleotide generates 5'-phosphate,3'-hydroxyl-product ?

Subunits

Subunits Comment Organism
More modeling of RNase P holoenzyme assembly, both the mitochondrial and nuclear enzyme complexes are composed of at least 10 protein subunits and 1 RNA subunit H1, overview Homo sapiens
oligomer 1 * 115000, protein subunit Pop1, + 1 * 40000, protein subunit Rpp40, + 1 * 38000, protein subunit Rpp38, + 1 * 30000, protein subunit Rpp30 or Rpp1, + 1 * 29000, protein subunit Rpp29 or Pop4, + 1 * 25000, protein subunit Rpp25, + 1 * 21000, protein subunit Rpp21 or Rpr2, + 1 * 20000, protein subunit Rpp20 or Pop7 or Rpp2, + 1 * 14000, protein subunit Rpp14, + 1 * 105000, RNA subunit H1 Homo sapiens
oligomer the nuclear RNase P complex has 1 RNA subunit and 9 distinct protein subunits essential for cell viability and tRNA processing, RNase MRP contains 8 protein subunit and 1 RNA subunit Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
nuclear ribonclease P ribonucleoprotein
-
 Homo sapiens
nuclear ribonclease P ribonucleoprotein
-
 Saccharomyces cerevisiae
ribosomal RNA processing ribonucleoprotein
-
 Homo sapiens
ribosomal RNA processing ribonucleoprotein
-
 Saccharomyces cerevisiae
RNase MRP
-
 Homo sapiens
RNase MRP
-
 Saccharomyces cerevisiae
RNase P
-
 Homo sapiens
RNase P
-
 Saccharomyces cerevisiae

pI Value

Organism Comment pI Value Maximum pI Value
Homo sapiens protein subunit Rpp20 4.7 4.6
Homo sapiens protein subunit Rpp30 4.7 4.6
Homo sapiens protein subunit Rpp40
-
 4.9
Homo sapiens protein subunit Rpp25
-
 5.5
Homo sapiens protein subunit Rpp29
-
 5.5
Homo sapiens protein subunits Pop1, Rpp21 and Rpp38
-
 5.5
Homo sapiens protein subunit Pop5
-
 6.9
Homo sapiens protein subunit Rpp14
-
 6.9