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Literature summary for 3.1.26.4 extracted from

  • Fuji, H.; Urano, E.; Futahashi, Y.; Hamatake, M.; Tatsumi, J.; Hoshino, T.; Morikawa, Y.; Yamamoto, N.; Komano, J.
    Derivatives of 5-nitrofuran-2-carboxylic acid carbamoyl methyl ester inhibit RNase H activity associated with HIV-1 reverse transcriptase (2009), J. Med. Chem., 52, 1380-1387.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
5-nitrofuran-2-carboxylic acid [[4-(4-bromophenyl)-thiazol-2-yl]-(tetrahydrofuran-2-ylmethyl)-carbamoyl]-methyl ester derivative of 5-nitrofuran-2-carboxylic acid carbamoyl methyl ester. 20-25 microM effectively inhibit HIV-1 replication Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA-RNA duplex + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
RNase H
-
Homo sapiens
RNase H1
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
no inhibitory activity against human RNase H1 for 5-nitrofuran-2-carboxylic acid adamantan-1-carbamoyl methyl ester Homo sapiens additional information
0.05
-
inhibitory activity against human RNase H1. IC50 value about 50 microM Homo sapiens 5-nitrofuran-2-carboxylic acid [[4-(4-bromophenyl)-thiazol-2-yl]-(tetrahydrofuran-2-ylmethyl)-carbamoyl] methyl ester