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Literature summary for 3.1.26.4 extracted from
- Studies on a calf thymus ribonuclease specific for ribonucleic acid-deoxyribonucleic acid hybrids (1973), Biochemistry, 12, 2389-2395.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| poly(rA) | noncompetitive | Bos taurus | |
| poly(rArU) | noncompetitive | Bos taurus | |
| poly(rCdG) | uncompetitive | Bos taurus | |
| poly(rIdC) | competitive | Bos taurus | |
| reovirus RNA | competitive | Bos taurus | |
| rifampicin | derivatives | Bos taurus |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0019 | - |
poly(rAdT) | - |
Bos taurus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| additional information | extranuclear | Bos taurus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | divalent cation required | Bos taurus | |
| Mg2+ | Mn2+ is preferred over Mg2+ | Bos taurus | |
| Mn2+ | divalent cation required | Bos taurus | |
| Mn2+ | Mn2+ is preferred over Mg2+ | Bos taurus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 76000 | - |
sedimentation equilibrium analysis | Bos taurus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
calf | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| calf | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| thymus | - |
Bos taurus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | no activity on natural double-stranded or single-stranded DNA, or on single-stranded RNA | Bos taurus | ? | - |
? | |
| poly(rAdT) + H2O | - |
Bos taurus | ? | - |
? | |
| RNA-DNA hybrid + H2O | poly(rAdT) | Bos taurus | ribonucleotide 5'-phosphomonoester | oligoribonucleotides + monoribonucleotides terminated by a 5'-phosphate | ? | |
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Release 2023.1 (January 2023)
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