Literature summary for 3.1.26.13 extracted from

Beilhartz, G.L.; Ngure, M.; Johns, B.A.; DeAnda, F.; Gerondelis, P.; Goette, M.
Inhibition of the ribonuclease H activity of HIV-1 reverse transcriptase by GSK5750 correlates with slow enzyme-inhibitor dissociation (2014), J. Biol. Chem., 289, 16270-16277.

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Inhibitors

Inhibitors	Comment	Organism	Structure
beta-thujaplicinol	weak inhibition at 0.05 mM	Human immunodeficiency virus 1
GSK5750	active site inhibitor	Human immunodeficiency virus 1
additional information	not inhibited by GSK5750	Human immunodeficiency virus 1

Organism

Organism	UniProt	Comment	Textmining
Human immunodeficiency virus 1	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
DNA-RNA/DNA hybrid + H2O	-	Human immunodeficiency virus 1	?	-	?

Synonyms

Synonyms	Comment	Organism
reverse transcriptase	-	Human immunodeficiency virus 1
reverse transcriptase	also shows ribonuclease H activity	Human immunodeficiency virus 1
ribonuclease H	-	Human immunodeficiency virus 1
RNase H	-	Human immunodeficiency virus 1

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00033	-	at pH 7.8 and 37°C	Human immunodeficiency virus 1	GSK5750
0.0038	-	at pH 7.8 and 37°C	Human immunodeficiency virus 1	beta-thujaplicinol

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Release 2023.1 (January 2023)