Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.26.13 extracted from

  • Singh, K.; Marchand, B.; Kirby, K.; Michailidis, E.; Sarafianos, S.
    Structural aspects of drug resistance and inhibition of HIV-1 reverse transcriptase (2010), Viruses, 2, 606-638.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
D67N mutation involved in zidovudine resistance Human immunodeficiency virus 1
E44A mutation involved in lamivudine resistance Human immunodeficiency virus 1
E44D mutation involved in lamivudine resistance Human immunodeficiency virus 1
E89K mutation involved in foscarnet resistance Human immunodeficiency virus 1
F227L mutation involved in non-nucleoside reverse transcriptase inhibitor resistance Human immunodeficiency virus 1
G190A mutation involved in non-nucleoside reverse transcriptase inhibitor resistance Human immunodeficiency virus 1
K103N mutation involved in non-nucleoside reverse transcriptase inhibitor resistance Human immunodeficiency virus 1
K219Q mutation involved in zidovudine resistance Human immunodeficiency virus 1
K65R mutation involved in nucleos(t)ide reverse transcriptase inhibitor resistance Human immunodeficiency virus 1
K65R/Q151M/A62V/V75I/F77L/F116Y mutation involved in nucleos(t)ide reverse transcriptase inhibitor resistance Human immunodeficiency virus 1
K70R mutation involved in zidovudine resistance Human immunodeficiency virus 1
L100I mutation involved in non-nucleoside reverse transcriptase inhibitor resistance Human immunodeficiency virus 1
L210W mutation involved in zidovudine resistance Human immunodeficiency virus 1
L74V mutation involved in nucleos(t)ide reverse transcriptase inhibitor resistance Human immunodeficiency virus 1
M41L mutation involved in zidovudine resistance Human immunodeficiency virus 1
Q151M mutation involved in nucleos(t)ide reverse transcriptase inhibitor resistance Human immunodeficiency virus 1
Q151M/A62V/V75I/F77L/F116Y mutation involved in nucleos(t)ide reverse transcriptase inhibitor resistance Human immunodeficiency virus 1
T215F mutation involved in zidovudine resistance Human immunodeficiency virus 1
T215Y mutation involved in zidovudine resistance Human immunodeficiency virus 1
V106A mutation involved in non-nucleoside reverse transcriptase inhibitor resistance Human immunodeficiency virus 1
W88G mutation involved in foscarnet resistance Human immunodeficiency virus 1
Y181C mutation involved in non-nucleoside reverse transcriptase inhibitor resistance Human immunodeficiency virus 1
Y188C mutation involved in non-nucleoside reverse transcriptase inhibitor resistance Human immunodeficiency virus 1
Y188L mutation involved in non-nucleoside reverse transcriptase inhibitor resistance Human immunodeficiency virus 1

Inhibitors

Inhibitors Comment Organism Structure
1-(2-hydroxyethoxymethyl)-6-(phenylthio)thymine
-
Human immunodeficiency virus 1
2',3'-dideoxy-3'-triaz-2-en-2-ium-3-id-1-yl-3,4-dihydrothymidine
-
Human immunodeficiency virus 1
3-[4-(2-methyl-imidazo[4,5-c]pyridin-1-yl)-benzyl]-3H-benzothiazol-2-one
-
Human immunodeficiency virus 1
Abacavir
-
Human immunodeficiency virus 1
Delavirdine
-
Human immunodeficiency virus 1
didanosine
-
Human immunodeficiency virus 1
efavirenz
-
Human immunodeficiency virus 1
Emtricitabine
-
Human immunodeficiency virus 1
Etravirine
-
Human immunodeficiency virus 1
Foscarnet
-
Human immunodeficiency virus 1
lamivudine
-
Human immunodeficiency virus 1
loviride
-
Human immunodeficiency virus 1
additional information mechanisms of catalysis and drug inhibition of polymerase and RNase H functions of RT by nucleos(t)ide reverse transcriptase inhibitor and non-nucleoside reverse transcriptase inhibitor drugs, and molecular mechanisms of drug resistance, detailed overview Human immunodeficiency virus 1
nevirapine
-
Human immunodeficiency virus 1
stavudine
-
Human immunodeficiency virus 1
tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one
-
Human immunodeficiency virus 1

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
51000
-
1 * 51000, p51 subunit, + 1 * 66000, p66 subunit, of HIV reverse transcriptase, SDS-PAGE Human immunodeficiency virus 1
66000
-
1 * 51000, p51 subunit, + 1 * 66000, p66 subunit, of HIV reverse transcriptase, SDS-PAGE Human immunodeficiency virus 1

Organism

Organism UniProt Comment Textmining
Human immunodeficiency virus 1
-
HIV-1
-

Subunits

Subunits Comment Organism
dimer 1 * 51000, p51 subunit, + 1 * 66000, p66 subunit, of HIV reverse transcriptase, SDS-PAGE Human immunodeficiency virus 1

Synonyms

Synonyms Comment Organism
RNase H
-
Human immunodeficiency virus 1

General Information

General Information Comment Organism
additional information the RNase H activity, which degrades RNA from RNA/DNA hybrids endonucleolytically, is part of the HIV reverse transcriptase Human immunodeficiency virus 1
physiological function the reverse transcriptase generates an RNA/DNA hybrid that is a substrate for RNase H. The RNA/DNA hybrid is degraded to generate a nascent minus-strand single-stranded DNA. As DNA synthesis proceeds, RNase H degrades the RNA strand Human immunodeficiency virus 1