Literature summary for 3.1.26.13 extracted from

Cirino, N.M.; Kalayjian, R.C.; Jentoft, J.E.; Le Grice, S.F.
Fluorimetric analysis of recombinant p15 HIV-1 ribonuclease H (1993), J. Biol. Chem., 268, 14743-14749.

Search for more literature for 3.1.26.13

Cloned(Commentary)

Cloned (Comment)	Organism
isolated 125-residue RNase H domain consisiting of residues G436-L560 of polypepitde p6	Human immunodeficiency virus 1

Protein Variants

Protein Variants	Comment	Organism
E478Q	mutation in isolated RNase H domain, mutant fails to bind RNA/DNA hybrids. Structure of mutant is similar to wild-type	Human immunodeficiency virus 1
H539F	mutation in isolated RNase H domain, mutant fails to bind RNA/DNA hybrids. Structure of mutant is similar to wild-type	Human immunodeficiency virus 1

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
additional information	-	poly(rA)/oligo(dT)	apparent binding constant 3500 per mM	Human immunodeficiency virus 1

Organism

Organism	UniProt	Comment	Textmining
Human immunodeficiency virus 1	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
poly(rA)/oligo(dT) + H2O	synthetic hybrid	Human immunodeficiency virus 1	?	-	?

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Release 2023.1 (January 2023)