Literature summary for 3.1.26.13 extracted from

Schultz, S.J.; Zhang, M.; Champoux, J.J.
Sequence, distance, and accessibility are determinants of 5'-end-directed cleavages by retroviral RNases H (2006), J. Biol. Chem., 281, 1943-1955.

Organism

Organism	UniProt	Comment	Textmining
Human immunodeficiency virus 1	-	-	-
Moloney murine leukemia virus	-	-	-

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the selection of 5' end-directed cleavage sites by retroviral RNases H results from a combination of nucleotide sequence, permissible distance, and accessibility to the RNA 5' end. Enzyme strongly prefers A or U at the +1 position and C or G at the -2 position, and A is disfavored at the -4 position. 5' End-directed cleavages occur when sites are positioned between the 13th and 20th nucleotides from the RNA 5' end. The extent of 5' end-directed cleavages observed in substrates containing a free recessed RNA 5' end is most comparable to substrates with a gap of 2 or 3 bases between the upstream and downstream RNAs	Human immunodeficiency virus 1	?	-	?
additional information	the selection of 5' end-directed cleavage sites by retroviral RNases H results from a combination of nucleotide sequence, permissible distance, and accessibility to the RNA 5' end. Enzyme strongly prefers A or U at the +1 position and C or G at the -2 position. 5' End-directed cleavages occurr when sites are positioned between the 13th and 20th nucleotides from the RNA 5' end. The extent of 5' end-directed cleavages observed in substrates containing a free recessed RNA 5' end is most comparable to substrates with a gap of 2 or 3 bases between the upstream and downstream RNAs	Moloney murine leukemia virus	?	-	?