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Literature summary for 3.1.26.13 extracted from

  • Sevilya, Z.; Loya, S.; Hughes, S.H.; Hizi, A.
    The ribonuclease H activity of the reverse transcriptases of human immunodeficiency viruses type 1 and type 2 is affected by the thumb subdomain of the small protein subunits (2001), J. Mol. Biol., 311, 957-971.
    View publication on PubMed
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Protein Variants

Protein Variants Comment Organism
additional information construction of chimeric HIV-1/HIV-2 reverse transcriptases, in which protein segments and/or subunits are exchanged. The RNase H specific activity of the chimeric enzymes is either high like HIV-1 reverse transcriptase or low like HIV-2 reverse transcriptase. The origin of the thumb subdomain in the small subunit of the chimeric reverse transcriptases, residues 244-322 determines the level of the RNase H activity Human immunodeficiency virus 1
additional information construction of chimeric HIV-1/HIV-2 reverse transcriptases, in which protein segments and/or subunits are exchanged. The RNase H specific activity of the chimeric enzymes is either high like HIV-1 reverse transcriptase or low like HIV-2 reverse transcriptase. The origin of the thumb subdomain in the small subunit of the chimeric reverse transcriptases, residues 244-322 determines the level of the RNase H activity Human immunodeficiency virus 2

Organism

Organism UniProt Comment Textmining
Human immunodeficiency virus 1
-
-
-
Human immunodeficiency virus 2
-
 low level of RNase H activity
-
Human immunodeficiency virus 2 D-194
-
 low level of RNase H activity
-
Human immunodeficiency virus 2 ROD
-
 low level of RNase H activity
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 level of RNase H activity is low in HIV-2 isolates Human immunodeficiency virus 2