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Literature summary for 3.1.26.11 extracted from

  • Xie, X.; Dubrovskaya, V.; Yacoub, N.; Walska, J.; Gleason, T.; Reid, K.; Dubrovsky, E.B.
    Developmental roles of Drosophila tRNA processing endonuclease RNase ZL as revealed with a conditional rescue system (2013), Dev. Biol., 381, 324-340.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.26.11

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
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Source Tissue

Source Tissue Comment Organism Textmining
central nervous system predominant expression during the third larval instar Drosophila melanogaster
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fat body
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 Drosophila melanogaster
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gonad
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 Drosophila melanogaster
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gut
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 Drosophila melanogaster
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larva
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 Drosophila melanogaster
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prepupa
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 Drosophila melanogaster
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salivary gland
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 Drosophila melanogaster
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testis
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 Drosophila melanogaster
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Synonyms

Synonyms Comment Organism
RNase ZL
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 Drosophila melanogaster
RNaseZ
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 Drosophila melanogaster

General Information

General Information Comment Organism
malfunction RNZED24 knockout mutation causes early larval lethality. RNaseZ knockout completely blocks tRNA maturation without diminishing the abundance of mature tRNA molecules, affects the nuclear-cytoplasmic distribution of tRNA, decreases cell proliferation but not cell survival, and affects maginal disc growth autonomously Drosophila melanogaster
physiological function RNase Z activity is essential for all phases of fly development that involve cell division, including growth of adult tissue progenitors during larval and metamorphic stages, and gametogenesis in adults Drosophila melanogaster