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Literature summary for 3.1.26.11 extracted from

  • Rossmanith, W.
    Localization of human RNase Z isoforms: dual nuclear/mitochondrial targeting of the ELAC2 gene product by alternative translation initiation (2011), PLoS ONE, 6, e19152.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expression of EGFP-tagged isozymes in HEK 293 cells. Alternative translation initiation is responsible for the dual targeting of RNase ZL. Due to the unfavorable context of the first AUG of ELAC2, translation apparently also starts from the second AUG, whereby the mitochondrial targeting sequence is lost and the protein is instead routed to the nucleus Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol isozyme RNase ZS Homo sapiens 5829
-
mitochondrion isozyme RNase ZL, alternative translation initiation is responsible for the dual targeting of RNase ZL Homo sapiens 5739
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nucleus isozyme RNase ZL, alternative translation initiation is responsible for the dual targeting of RNase ZL Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 genes ELAC1 and ELAC2, two isozymes
-

Synonyms

Synonyms Comment Organism
tRNase Z
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function RNase Z is an endonuclease responsible for the removal of 39 extensions from tRNA precursors, an essential step in tRNA biogenesis. Human cells contain a long form RNase ZL, encoded by ELAC2, and a short form RNase ZS, ELAC1. Isozyme RNase ZL is the enzyme involved in both, nuclear and mitochondrial tRNA 39 end maturation Homo sapiens