Literature summary for 3.1.22.1 extracted from

Ohkouchi, S.; Shibata, M.; Sasaki, M.; Koike, M.; Safig, P.; Peters, C.; Nagata, S.; Uchiyama, Y.
Biogenesis and proteolytic processing of lysosomal DNase II (2013), PLoS ONE, 8, e59148.

Search for more literature for 3.1.22.1

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
lysosome	and heterophagolysosome of macrophages and mononuclear cells, two bands with strong immunoreactivity appear at molecular masses of 30 and 23 kDa	Mus musculus	5764	-
microsome	45-kDa form of recombinant DNase II	Mus musculus	-	-

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	processing of DNase II in vivo is greatly altered in the liver of mice lacking cathepsin L. DNase II is extracellularly secreted from cells overexpressing DNase II and is detected as a pro-form, which is activated under acidic conditions. In transgenic COS1 cells, a band of 45 kDa colocalizeswith ER marker protein Bip and two bands with strong immunoreactivity appear at molecular masses of 30 and 23 kDa in lysosomes	Mus musculus

Purification (Commentary)

Purification (Comment)	Organism
partial purification using Con A Sepharose	Mus musculus

Source Tissue

Source Tissue	Comment	Organism	Textmining
bone marrow	-	Mus musculus	-
liver	-	Mus musculus	-
macrophage	CD68-positive macrophage	Mus musculus	-
mononuclear cell	-	Mus musculus	-
spleen	immunoreactivity is granular and localized in the red pulp	Mus musculus	-

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Release 2023.1 (January 2023)