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Literature summary for 3.1.22.1 extracted from

  • Padron-Barthe, L.; Lepretre, C.; Martin, E.; Counis, M.F.; Torriglia, A.
    Conformational modification of serpins transforms leukocyte elastase inhibitor into an endonuclease involved in apoptosis (2007), Mol. Cell. Biol., 27, 4028-4036.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Sus scrofa enzyme precursor Leukocyte Elastase Inhibitor is cleaved by elastase at its reactive center loop. Cleavage abolishes the antiprotease activity and leads to a conformational modification that exposes an endonuclease active site and a nuclear localization signal. Both endonuclease activity and nuclear translocation are needed to induce cell death ?
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Organism

Organism UniProt Comment Textmining
Sus scrofa
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 isoform LEI-DNase, L-DNase II
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Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification enzyme precursor Leukocyte Elastase Inhibitor is cleaved by elastase at its reactive center loop. Cleavage abolishes the antiprotease activity and leads to a conformational modification that exposes an endonuclease active site and a nuclear localization signal. Both endonuclease activity and nuclear translocation are needed to induce cell death Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme precursor Leukocyte Elastase Inhibitor is cleaved by elastase at its reactive center loop. Cleavage abolishes the antiprotease activity and leads to a conformational modification that exposes an endonuclease active site and a nuclear localization signal. Both endonuclease activity and nuclear translocation are needed to induce cell death Sus scrofa ?
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 ?