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Literature summary for 3.1.22.1 extracted from
- Molecular cloning and characterization of human and murine DNase II (1998), Gene, 215, 281-289.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in human embryonic kidney 293 cells | Mus musculus |
| expression in human embryonic kidney 293 cells | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | 20-30% secreted | Mus musculus | - |
- |
| extracellular | 20-30% secreted | Homo sapiens | - |
- |
| extracellular | 20-30% secreted | Sus scrofa | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 10000 | - |
1 * 35000 + 1 * 10000, protein sequence analysis | Sus scrofa |
| 35000 | - |
1 * 35000 + 1 * 10000, protein sequence analysis | Sus scrofa |
| 38030 | - |
calculation from cDNA sequence | Homo sapiens |
| 42000 | 44000 | SDS-PAGE, mature protein | Homo sapiens |
| 45000 | - |
- |
Homo sapiens |
| 45000 | - |
protein sequence analysis of a 35000 and 10000 Da protein band | Sus scrofa |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| DNA + H2O | Mus musculus | directed into the secretory pathway | oligonucleotides + ? | - |
? |  |
| DNA + H2O | Homo sapiens | directed into the secretory pathway | oligonucleotides + ? | - |
? | |
| DNA + H2O | Sus scrofa | directed into the secretory pathway | oligonucleotides + ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Sus scrofa | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | - |
Homo sapiens |
| glycoprotein | - |
Sus scrofa |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| commercially available DNase II further purified by chromatography steps to homogeneity | Sus scrofa |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cell culture | - |
Mus musculus | - |
| cell culture | - |
Homo sapiens | - |
| liver | - |
Mus musculus | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Sus scrofa | - |
| placenta | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| DNA + H2O | - |
Sus scrofa | oligonucleotides + ? | - |
? | |
| DNA + H2O | salmon sperm DNA | Mus musculus | oligonucleotides + ? | - |
? | |
| DNA + H2O | salmon sperm DNA | Homo sapiens | oligonucleotides + ? | - |
? | |
| DNA + H2O | directed into the secretory pathway | Mus musculus | oligonucleotides + ? | - |
? | |
| DNA + H2O | directed into the secretory pathway | Homo sapiens | oligonucleotides + ? | - |
? | |
| DNA + H2O | directed into the secretory pathway | Sus scrofa | oligonucleotides + ? | - |
? | |
| supercoiled plasmid DNA + H2O | plasmid pBR322 | Mus musculus | relaxed plasmid DNA + ? | primary reaction product, "nicking" mechanism | ? | |
| supercoiled plasmid DNA + H2O | plasmid pBR322 | Homo sapiens | relaxed plasmid DNA + ? | primary reaction product, "nicking" mechanism | ? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 1 * 35000 + 1 * 10000, protein sequence analysis | Sus scrofa |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 4.6 | - |
- |
Mus musculus |
| 4.6 | - |
- |
Homo sapiens |
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