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Literature summary for 3.1.21.7 extracted from

  • McCullough, A.K.; Dodson, M.L.; Schärer, O.D.; Lloyd, R.S.
    The role pf base flipping in damge recognition and catalysis by nT4 endonuclease V (1997), J. Biol. Chem., 272, 27210-27217.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Tequatrovirus T4

Protein Variants

Protein Variants Comment Organism
E23Q no detection of base movement prior to catalysis Tequatrovirus T4

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA + H2O Tequatrovirus T4 pyrimidine dimer-specific 5'-phosphoryltermini DNA + 3'-hydroxyltermini DNA
-
?
DNA + H2O Tequatrovirus T4 moving a DNA base extrahelical opposite the target site that induces a conformational change to facilitate catalysis 5'-phosphoryltermini DNA + 3'-hydroxyltermini DNA
-
?

Organism

Organism UniProt Comment Textmining
Tequatrovirus T4
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Tequatrovirus T4

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
49-mer oligonucleotide + H2O also possesses abasic lyase activity Tequatrovirus T4 hydrolysed DNA
-
?
49-mer oligonucleotide + H2O double-stranded, containing a site-specific duplex cis-syn cyclobutane pyrimidine dimer Tequatrovirus T4 hydrolysed DNA
-
?
DNA + H2O abasic lyase activity Tequatrovirus T4 3-alpha,beta-unsaturated aldehyde + 5'-phosphate DNA-termini
-
?
DNA + H2O pyrimidine dimer-specific Tequatrovirus T4 5'-phosphoryltermini DNA + 3'-hydroxyltermini DNA
-
?
DNA + H2O moving a DNA base extrahelical opposite the target site that induces a conformational change to facilitate catalysis Tequatrovirus T4 5'-phosphoryltermini DNA + 3'-hydroxyltermini DNA
-
?

Synonyms

Synonyms Comment Organism
T4 endonuclease V
-
Tequatrovirus T4