Literature summary for 3.1.2.4 extracted from

Zamani, M.; diCenzo, G.C.; Milunovic, B.; Finan, T.M.
A putative 3-hydroxyisobutyryl-CoA hydrolase is required for efficient symbiotic nitrogen fixation in Sinorhizobium meliloti and Sinorhizobium fredii NGR234 (2017), Environ. Microbiol., 19, 218-236 .

Search for more literature for 3.1.2.4

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
(S)-3-hydroxyisobutyryl-CoA + H2O	Sinorhizobium meliloti	-	CoA + (S)-3-hydroxyisobutyrate	-	ir
(S)-3-hydroxyisobutyryl-CoA + H2O	Sinorhizobium fredii	-	CoA + (S)-3-hydroxyisobutyrate	-	ir
(S)-3-hydroxyisobutyryl-CoA + H2O	Sinorhizobium fredii NGR234	-	CoA + (S)-3-hydroxyisobutyrate	-	ir
(S)-3-hydroxyisobutyryl-CoA + H2O	Sinorhizobium meliloti RmP798	-	CoA + (S)-3-hydroxyisobutyrate	-	ir

Organism

Organism	UniProt	Comment	Textmining
Sinorhizobium fredii	C3KM96	-	-
Sinorhizobium fredii NGR234	C3KM96	-	-
Sinorhizobium meliloti	-	-	-
Sinorhizobium meliloti RmP798	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(S)-3-hydroxyisobutyryl-CoA + H2O	-	Sinorhizobium meliloti	CoA + (S)-3-hydroxyisobutyrate	-	ir
(S)-3-hydroxyisobutyryl-CoA + H2O	-	Sinorhizobium fredii	CoA + (S)-3-hydroxyisobutyrate	-	ir
(S)-3-hydroxyisobutyryl-CoA + H2O	-	Sinorhizobium fredii NGR234	CoA + (S)-3-hydroxyisobutyrate	-	ir
(S)-3-hydroxyisobutyryl-CoA + H2O	-	Sinorhizobium meliloti RmP798	CoA + (S)-3-hydroxyisobutyrate	-	ir

Synonyms

Synonyms	Comment	Organism
HIB-CoA hydrolase	-	Sinorhizobium meliloti
HIB-CoA hydrolase	-	Sinorhizobium fredii
NGR_b20860	-	Sinorhizobium fredii
Smb20752	-	Sinorhizobium meliloti
VutE	-	Sinorhizobium meliloti

General Information

General Information	Comment	Organism
malfunction	enzyme deletion results in a loss of symbiotic N2-fixation	Sinorhizobium meliloti
malfunction	enzyme deletion results in a loss of symbiotic N2-fixation	Sinorhizobium fredii
metabolism	the enzyme is required for L-valine catabolism and prevents the accumulation of toxic metabolic intermediates, particularly methacrylyl-CoA	Sinorhizobium meliloti
metabolism	the enzyme is required for L-valine catabolism and prevents the accumulation of toxic metabolic intermediates, particularly methacrylyl-CoA	Sinorhizobium fredii
physiological function	the enzyme is required for efficient symbiotic nitrogen fixation	Sinorhizobium meliloti
physiological function	the enzyme is required for efficient symbiotic nitrogen fixation	Sinorhizobium fredii

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)