Literature summary for 3.1.2.22 extracted from

Kim, S.J.; Zhang, Z.; Sarkar, C.; Tsai, P.C.; Lee, Y.C.; Dye, L.; Mukherjee, A.B.
Palmitoyl protein thioesterase-1 deficiency impairs synaptic vesicle recycling at nerve terminals, contributing to neuropathology in humans and mice (2008), J. Clin. Invest., 118, 3075-3086.

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Cloned(Commentary)

Cloned (Comment)	Organism
PPT1-KO mice are generated by gene targeting in ES cells	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
synaptic vesicle	-	Mus musculus	8021	-
synaptic vesicle	-	Homo sapiens	8021	-
synaptosome	-	Mus musculus	-	-
synaptosome	-	Homo sapiens	-	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Mus musculus	PPT1 deficiency leads to abnormally low levels of soluble synaptic vesicle proteins like synaptobrevin 2 and SNAP25, that are known to undergo palmitoylation and are critical for fusion, exocytosis, recycling, and regeneration of fresh synaptic vesicles	?	-	?
additional information	Homo sapiens	PPT1 deficiency leads to abnormally low levels of soluble synaptic vesicle proteins like synaptobrevin 2 and SNAP25, that are known to undergo palmitoylation and are critical for fusion, exocytosis, recycling, and regeneration of fresh synaptic vesicles	?	-	?
palmitoyl-[protein] + H2O	Mus musculus	palmitoylation plays critical roles in diverse biological functions, including membrane anchorage, vesicular transport, signal transduction and the maintenance of cellular architecture	palmitate + protein	-	r
palmitoyl-[protein] + H2O	Homo sapiens	palmitoylation plays critical roles in diverse biological functions, including membrane anchorage, vesicular transport, signal transduction and the maintenance of cellular architecture	palmitate + protein	-	r

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	postmortem from patient with infantile neuronal ceroid lipofuscinosis (INCL) caused by PPT1 deficiency	Homo sapiens	-
neuronal cell line	primary cortical neuron culture from tissue of PPT1 knockout mice that mimic infantile neuronal ceroid lipofuscinosis	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	PPT1 deficiency leads to abnormally low levels of soluble synaptic vesicle proteins like synaptobrevin 2 and SNAP25, that are known to undergo palmitoylation and are critical for fusion, exocytosis, recycling, and regeneration of fresh synaptic vesicles	Mus musculus	?	-	?
additional information	PPT1 deficiency leads to abnormally low levels of soluble synaptic vesicle proteins like synaptobrevin 2 and SNAP25, that are known to undergo palmitoylation and are critical for fusion, exocytosis, recycling, and regeneration of fresh synaptic vesicles	Homo sapiens	?	-	?
palmitoyl-[protein] + H2O	palmitoylation plays critical roles in diverse biological functions, including membrane anchorage, vesicular transport, signal transduction and the maintenance of cellular architecture	Mus musculus	palmitate + protein	-	r
palmitoyl-[protein] + H2O	palmitoylation plays critical roles in diverse biological functions, including membrane anchorage, vesicular transport, signal transduction and the maintenance of cellular architecture	Homo sapiens	palmitate + protein	-	r

Synonyms

Synonyms	Comment	Organism
palmitoyl protein thioesterase-1	-	Mus musculus
palmitoyl protein thioesterase-1	-	Homo sapiens
PPT1	-	Mus musculus
PPT1	-	Homo sapiens

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Release 2023.1 (January 2023)