Cloned (Comment) | Organism |
---|---|
expression as glutathione S-transferase fusion protein in BHK and CHO cells, localization of the recombinant enzyme out side the lysosomes and endosomes | Mus musculus |
expression of the enzyme in Caco-2 cells, orientation to the basolateral side, also after endocytosis of the recombinant enzyme into Caco-2 cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | enzyme is recognized by the mannose 6-phosphate receptor and routed to the lysosome | Homo sapiens | 5764 | - |
additional information | not in lysosomes of mouse brain or neurons | Mus musculus | - |
- |
synaptic vesicle | - |
Mus musculus | 8021 | - |
synaptosome | - |
Mus musculus | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
37000 | - |
x * 37000, SDS-PAGE | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | enzyme deficiency causes progressive neurological disorder infantile neuronal ceroid lipofuscinosis, INCL | ? | - |
? | |
additional information | Mus musculus | the enzyme has a role outside the lysosome in the brain and might be associated with synaptic functioning | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
palmitoyl[protein] + H2O = palmitate + protein | specific for long-chain thioesters of fatty acids from S-acylated residues in proteins, palmitoyl cysteine and palmitoyl-CoA | Mus musculus | |
palmitoyl[protein] + H2O = palmitate + protein | specific for long-chain thioesters of fatty acids from S-acylated residues in proteins, palmitoyl cysteine and palmitoyl-CoA | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
brain | - |
Homo sapiens | - |
Caco-2 cell | exclusively localized to the basolateral side of the polarized cells | Homo sapiens | - |
epithelium | - |
Homo sapiens | - |
neuron | - |
Mus musculus | - |
neuron | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | enzyme deficiency causes progressive neurological disorder infantile neuronal ceroid lipofuscinosis, INCL | Homo sapiens | ? | - |
? | |
additional information | the enzyme has a role outside the lysosome in the brain and might be associated with synaptic functioning | Mus musculus | ? | - |
? | |
palmitoyl-[protein] + H2O | - |
Mus musculus | palmitate + protein | - |
? | |
palmitoyl-[protein] + H2O | - |
Homo sapiens | palmitate + protein | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 37000, SDS-PAGE | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
palmitoyl protein thioesterase | - |
Mus musculus |
palmitoyl protein thioesterase | - |
Homo sapiens |
PPT | - |
Mus musculus |
PPT | - |
Homo sapiens |