Literature summary for 3.1.2.2 extracted from

Neuman, I.; Maloberti, P.; Lisdero, C.; Colonna, C.; Peralta, J.; Jose Poderoso, J.; Podesta, E.J.
b-Adrenergic stimulation controls the expression of a thioesterase specific for very-long-chain fatty acids in perfused hearts (2002), Biochem. Biophys. Res. Commun., 299, 135-141.

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Activating Compound

Activating Compound	Comment	Organism	Structure
isoproterenol	stimulates enzyme expression, can be blocked by specific beta-adrenoreceptor antagonists, e.g. actinomycin D	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
arachidonoyl-CoA + H2O	Rattus norvegicus	enzyme is responsible for the mobilization of stored arachidonic acid in cells	CoA + arachidonate	-	?
arachidonoyl-CoA + H2O	Rattus norvegicus	regulation, e.g. in the heart, of the enzyme is performed via beta-adrenergic receptors and their antagonists, e.g. actinomycin D	CoA + arachidonate	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	Wistar rats	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
heart	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acyl-CoA + H2O	specific for very-long acyl-CoA	Rattus norvegicus	CoA + a carboxylate	-	?
arachidonoyl-CoA + H2O	-	Rattus norvegicus	CoA + arachidonate	-	?
arachidonoyl-CoA + H2O	enzyme is responsible for the mobilization of stored arachidonic acid in cells	Rattus norvegicus	CoA + arachidonate	-	?
arachidonoyl-CoA + H2O	regulation, e.g. in the heart, of the enzyme is performed via beta-adrenergic receptors and their antagonists, e.g. actinomycin D	Rattus norvegicus	CoA + arachidonate	-	?

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Release 2023.1 (January 2023)