Literature summary for 3.1.2.1 extracted from

Fleck, C.B.; Brock, M.
Re-characterisation of Saccharomyces cerevisiae Ach1p: fungal CoA-transferases are involved in acetic acid detoxification (2009), Fungal Genet. Biol., 46, 473-485.

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Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	isoform Ach1p catalyzes CoASH transfer from succinyl-CoA to acetate and shows only a minor acetyl-CoA-hydrolase activity. When the activity with different substrate couples is compared to that with propionyl-CoA and acetate, CoA-transferase activity increases by a factor of 3.6 with the couple succinyl-CoA and propionate and by a factor of 7.4 with the couple succinyl-CoA and acetate	Saccharomyces cerevisiae	?	-	?

General Information

General Information	Comment	Organism
physiological function	complementation of an ach1 mutant with the coaT gene reverses the growth defect on acetate confirming the in vivo function of Ach1p as a CoA-transferase. Growth of an ach1p deletion mutant on the carboxylic acids lactate and pyruvate reveals no phenotype	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)