Literature summary for 3.1.13.2 extracted from

Santos, A.F.; Lengruber, R.B.; Soares, E.A.; Jere, A.; Sprinz, E.; Martinez, A.M.; Silveira, J.; Sion, F.S.; Pathak, V.K.; Soares, M.A.
Conservation patterns of HIV-1 RT connection and RNase H domains: identification of new mutations in NRTI-treated patients (2008), PLoS ONE, 3, e1781.

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Protein Variants

Protein Variants	Comment	Organism
additional information	identification of mutations in nucleoside reverse transcriptase inhibitor-treated patients. 3 mutations are found exclusively in nucleoside reverse transcriptase inhibitor-treated isolates. 9 mutations in the connection and 6 mutations in the RNase H are associated with nucleoside reverse transcriptase inhibitor treatment in subtype B. Some of them lay in or close to amino acid residues which contact nucleic acid or near the RNase H active site. Several of the residues have been recently associated to nucleoside reverse transcriptase inhibitor exposure or increase drug resistance to nucleoside reverse transcriptase inhibitor	Human immunodeficiency virus 1

Organism

Organism	UniProt	Comment	Textmining
Human immunodeficiency virus 1	-	-	-

Synonyms

Synonyms	Comment	Organism
RNase H	-	Human immunodeficiency virus 1

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Release 2023.1 (January 2023)