Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,7-dihydroxyisoquinoline-1,3(2H,4H)-dione | - |
Human immunodeficiency virus 1 | |
2-(4-fluorophenyl)-N-(2-hydroxy-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-7-yl)acetamide | - |
Human immunodeficiency virus 1 | |
2-hydroxy-7-(4-hydroxyphenyl)isoquinoline-1,3(2H,4H)-dione | - |
Human immunodeficiency virus 1 | |
2-hydroxy-7-iodoisoquinoline-1,3(2H,4H)-dione | - |
Human immunodeficiency virus 1 | |
2-hydroxy-7-nitroisoquinoline-1,3(2H,4H)-dione | - |
Human immunodeficiency virus 1 | |
2-hydroxy-7-phenylisoquinoline-1,3(2H,4H)-dione | - |
Human immunodeficiency virus 1 | |
2-hydroxy-7-[4-(trifluoromethyl)phenyl]isoquinoline-1,3(2H,4H)-dione | - |
Human immunodeficiency virus 1 | |
2-hydroxyisoquinoline-1,3(2H,4H)-dione | - |
Human immunodeficiency virus 1 | |
7-(3,4-dihydroxyphenyl)-2-hydroxyisoquinoline-1,3(2H,4H)-dione | - |
Human immunodeficiency virus 1 | |
7-(4-fluorophenyl)-2-hydroxyisoquinoline-1,3(2H,4H)-dione | - |
Human immunodeficiency virus 1 | |
7-bromo-2-hydroxyisoquinoline-1,3(2H,4H)-dione | - |
Human immunodeficiency virus 1 | |
7-chloro-2-hydroxyisoquinoline-1,3(2H,4H)-dione | - |
Human immunodeficiency virus 1 | |
N-(2-hydroxy-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-7-yl)-2-phenylacetamide | - |
Human immunodeficiency virus 1 | |
N-(2-hydroxy-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-7-yl)-3-nitrobenzamide | - |
Human immunodeficiency virus 1 | |
N-(2-hydroxy-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-7-yl)-4-fluorobenzamide | - |
Human immunodeficiency virus 1 | |
N-(2-hydroxy-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-7-yl)acetamide | - |
Human immunodeficiency virus 1 | |
N-(2-hydroxy-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-7-yl)benzamide | - |
Human immunodeficiency virus 1 | |
N-(2-hydroxy-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-7-yl)pentanamide | - |
Human immunodeficiency virus 1 |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Human immunodeficiency virus 1 | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
HIV-1 RT ribonuclease H | - |
Human immunodeficiency virus 1 |
RNase H | reverse transcriptase RNase H domain | Human immunodeficiency virus 1 |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
additional information | - |
IC50 value is higher than 96.00 microM for 7-bromo-2-hydroxyisoquinoline-1,3(2H,4H)-dione. IC50 value is higher than 80.0 microM for N-(2-hydroxy-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-7-yl)pentanamide, for 2-hydroxy-7-phenylisoquinoline-1,3(2H,4H)-dione, and for N-(2-hydroxy-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-7-yl)-2-phenylacetamide. pH 8.0, 37°C | Human immunodeficiency virus 1 | additional information | |
0.0057 | - |
pH 8.0, 37°C | Human immunodeficiency virus 1 | N-(2-hydroxy-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-7-yl)benzamide | |
0.0059 | - |
pH 8.0, 37°C | Human immunodeficiency virus 1 | 2-hydroxyisoquinoline-1,3(2H,4H)-dione | |
0.0066 | - |
pH 8.0, 37°C | Human immunodeficiency virus 1 | 7-(3,4-dihydroxyphenyl)-2-hydroxyisoquinoline-1,3(2H,4H)-dione | |
0.0071 | - |
pH 8.0, 37°C | Human immunodeficiency virus 1 | N-(2-hydroxy-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-7-yl)-4-fluorobenzamide | |
0.0072 | - |
pH 8.0, 37°C | Human immunodeficiency virus 1 | 2-hydroxy-7-(4-hydroxyphenyl)isoquinoline-1,3(2H,4H)-dione | |
0.0107 | - |
pH 8.0, 37°C | Human immunodeficiency virus 1 | 2-hydroxy-7-[4-(trifluoromethyl)phenyl]isoquinoline-1,3(2H,4H)-dione | |
0.0108 | - |
pH 8.0, 37°C | Human immunodeficiency virus 1 | N-(2-hydroxy-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-7-yl)-3-nitrobenzamide | |
0.0222 | - |
pH 8.0, 37°C | Human immunodeficiency virus 1 | 7-(4-fluorophenyl)-2-hydroxyisoquinoline-1,3(2H,4H)-dione | |
0.0289 | - |
pH 8.0, 37°C | Human immunodeficiency virus 1 | 7-chloro-2-hydroxyisoquinoline-1,3(2H,4H)-dione | |
0.0353 | - |
pH 8.0, 37°C | Human immunodeficiency virus 1 | 2-(4-fluorophenyl)-N-(2-hydroxy-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-7-yl)acetamide | |
0.0374 | - |
pH 8.0, 37°C | Human immunodeficiency virus 1 | 2,7-dihydroxyisoquinoline-1,3(2H,4H)-dione | |
0.0407 | - |
pH 8.0, 37°C | Human immunodeficiency virus 1 | N-(2-hydroxy-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-7-yl)acetamide | |
0.048 | - |
pH 8.0, 37°C | Human immunodeficiency virus 1 | 2-hydroxy-7-nitroisoquinoline-1,3(2H,4H)-dione | |
0.058 | - |
pH 8.0, 37°C | Human immunodeficiency virus 1 | 2-hydroxy-7-iodoisoquinoline-1,3(2H,4H)-dione |