Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.13.2 extracted from

  • Wang, J.; Dykes, C.; Domaoal, R.A.; Koval, C.E.; Bambara, R.A.; Demeter, L.M.
    The HIV-1 reverse transcriptase mutants G190S and G190A, which confer resistance to non-nucleoside reverse transcriptase inhibitors, demonstrate reductions in RNase H activity and DNA synthesis from tRNALys,3 that correlate with reductions in replication effciciency (2006), Virology, 348, 462-474.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.13.2

Protein Variants

Protein Variants Comment Organism
G190A site-directed mutagenesis, the mutation confers resistance to non-nucleoside reverse transcriptase inhibitors, and leads to reduced RNase H activity of the reverse transcriptase and to reduced DNA synthesis from tRNALys,3 that correlate with reductions in replication efficiency, the mutant shows reduced fitness compared to the wild-type enzyme Human immunodeficiency virus 1
G190S site-directed mutagenesis, the mutation confers resistance to non-nucleoside reverse transcriptase inhibitors, and leads to reduced RNase H activity of the reverse transcriptase and to reduced DNA synthesis from tRNALys,3 that correlate with reductions in replication efficiency, the mutant shows highly reduced fitness compared to the wild-type enzyme Human immunodeficiency virus 1
K103N site-directed mutagenesis, the mutation confers resistance to non-nucleoside reverse transcriptase inhibitors, and leads to reduced RNase H activity of the reverse transcriptase and to reduced DNA synthesis from tRNALys,3 that correlate with reductions in replication efficiency, the mutant shows a fitness similar to the wild-type enzyme Human immunodeficiency virus 1

Inhibitors

Inhibitors Comment Organism Structure
efavirenz a non-nucleoside reverse transcriptase inhibitor Human immunodeficiency virus 1

Organism

Organism UniProt Comment Textmining
Human immunodeficiency virus 1
-
 i.e. HIV-1
-

Synonyms

Synonyms Comment Organism
RNase H
-
 Human immunodeficiency virus 1