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Literature summary for 3.1.13.2 extracted from

  • Dat, N.T.; Bae, K.; Wamiru, A.; McMahon, J.B.; Le Grice, S.F.; Bona, M.; Beutler, J.A.; Kim, Y.H.
    A dimeric lactone from Ardisia japonica with inhibitory activity for HIV-1 and HIV-2 ribonuclease H (2007), J. Nat. Prod., 70, 839-841.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
ardimerin digallate a Ardisia japonica dimeric lactone, structure determination by NMR spectrometry Human immunodeficiency virus 1
ardimerin digallate a Ardisia japonica dimeric lactone, structure determination by NMR spectrometry Human immunodeficiency virus 2

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Human immunodeficiency virus 1
Mg2+
-
 Human immunodeficiency virus 2

Organism

Organism UniProt Comment Textmining
Human immunodeficiency virus 1
-
 i.e. HIV-1
-
Human immunodeficiency virus 2
-
 i.e. HIV-2
-

Synonyms

Synonyms Comment Organism
ribonuclease H
-
 Human immunodeficiency virus 1
ribonuclease H
-
 Human immunodeficiency virus 2
RNase H
-
 Human immunodeficiency virus 1
RNase H
-
 Human immunodeficiency virus 2

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
 assay at room temperature Human immunodeficiency virus 1
22
-
 assay at room temperature Human immunodeficiency virus 2

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Human immunodeficiency virus 1
8
-
 assay at Human immunodeficiency virus 2

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0011
-
 pH 8.0, 22°C Human immunodeficiency virus 2 ardimerin digallate
0.0015
-
 pH 8.0, 22°C Human immunodeficiency virus 1 ardimerin digallate