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Literature summary for 3.1.11.5 extracted from
- Mu transpososome and RecBCD nuclease collaborate in the repair of simple Mu insertions (2014), Proc. Natl. Acad. Sci. USA, 111, 14112-14117.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| RecBCD | - |
Escherichia coli |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | after transposition of phage Mu into the Escherichia coli chromosome, the flanking DNA is degraded, and the 5-bp gaps left in the target are repaired to generate a simple Mu insertion. The first event in repair is removal of the flanking DNA by RecBCD exonuclease, whose entry past the N-protein block is licensed by the transpososome. When RecBCD is allowed entry into the flanking DNA, it degrades this DNA until it arrives at the transpososome, which presents a barrier for further RecBCD movement. RecBCD action is required for stimulating endonucleolytic cleavage within the transpososome-protected DNA, leaving 4-nt flanks outside both Mu ends | Escherichia coli |
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Release 2023.1 (January 2023)
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