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Literature summary for 3.1.11.1 extracted from

  • Vallur, A.C.; Maizels, N.
    Distinct activities of exonuclease 1 and flap endonuclease 1 at telomeric g4 DNA (2010), PLoS ONE, 5, e8908.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
additional information 3' G4 telomeric tails inhibit Flap cleavage by human exonuclease 1, but not by human endonuclease 1 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
Exo1
-
Homo sapiens
exonuclease 1
-
Homo sapiens
More exonuclease 1 is a member of the RAD2 family of structure-specific nucleases Homo sapiens

General Information

General Information Comment Organism
additional information comparison of exonuclease 1, EXO1, and Flap endonuclease 1, FEN1, activities on G4 DNA substrates, hFEN1, but not hEXO1, cleaves 59 telomeric G4 DNA, overview. Telomeres are composed of G-rich repeats that readily form G4 DNA. human EXO1 and FEN1 exhibit distinct activities on G4 DNA substrates representative of intermediates in immunoglobulin class switch recombination, distinct telomeric phenotypes caused by EXO1 and FEN1 deficiencies, overview Homo sapiens