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Literature summary for 3.1.11.1 extracted from

  • Bahmed, K.; Seth, A.; Nitiss, K.C.; Nitiss, J.L.
    End-processing during non-homologous end-joining: a role for exonuclease 1 (2011), Nucleic Acids Res., 39, 970-978.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
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Saccharomyces cerevisiae 5634
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Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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-
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Saccharomyces cerevisiae BY4741
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-
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Synonyms

Synonyms Comment Organism
Exo1
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Saccharomyces cerevisiae
exonuclease 1
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Saccharomyces cerevisiae

General Information

General Information Comment Organism
malfunction enzyme-deficient exo1DELTA yeast cells repairing plasmids with 5'-extensions can produce repair junction with templated insertions. Exo1D mutants have a reduced median size of deletions when joining DNA with blunt ends, and exo1D pol4D mutants repair blunt ends with a very low frequency of deletions, phenotypes, overview Saccharomyces cerevisiae
physiological function Exo1 acts at a late stage in end-processing during non-homologous end-joining, NHEJ. Exo1 can reverse nucleotide additions occurring due to polymerization, and may also be important for processing ends to expose microhomologies needed for NHEJ. Acurate joining is controlled at two steps, a first step that blocks mdification of DNA ends, which requires Tdp1, and a second step that occurs after synapsis that requires Exo1, overview Saccharomyces cerevisiae