Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Saccharomyces cerevisiae | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Saccharomyces cerevisiae BY4741 | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
Exo1 | - |
Saccharomyces cerevisiae |
exonuclease 1 | - |
Saccharomyces cerevisiae |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme-deficient exo1DELTA yeast cells repairing plasmids with 5'-extensions can produce repair junction with templated insertions. Exo1D mutants have a reduced median size of deletions when joining DNA with blunt ends, and exo1D pol4D mutants repair blunt ends with a very low frequency of deletions, phenotypes, overview | Saccharomyces cerevisiae |
physiological function | Exo1 acts at a late stage in end-processing during non-homologous end-joining, NHEJ. Exo1 can reverse nucleotide additions occurring due to polymerization, and may also be important for processing ends to expose microhomologies needed for NHEJ. Acurate joining is controlled at two steps, a first step that blocks mdification of DNA ends, which requires Tdp1, and a second step that occurs after synapsis that requires Exo1, overview | Saccharomyces cerevisiae |