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Literature summary for 3.1.1.8 extracted from

  • Torres, J.M.; Lira, A.F.; Silva, D.R.; Guzzo, L.M.; SantAnna, C.M.; Kuemmerle, A.E.; Rumjanek, V.M.
    Structural insights into cholinesterases inhibition by harmane beta-carbolinium derivatives: A kinetics-molecular modeling approach (2012), Phytochemistry, 81, 24-30.
    View publication on PubMed
Search for more literature for 3.1.1.8

Inhibitors

Inhibitors Comment Organism Structure
1,2-dimethyl-beta-carbolin-2-ium iodide noncompetitive inhibition Equus caballus
2-ethyl-1-methyl-beta-carbolin-2-ium iodide noncompetitive inhibition Equus caballus
6-chloro-2-methyl-9H-beta-carbolin-2-ium iodide
-
 Equus caballus
6-methoxy-1,2-dimethyl-9H-beta-carbolin-2-ium iodide
-
 Equus caballus
galantamine
-
 Equus caballus
Harmane noncompetitive inhibition Equus caballus
physostigmine
-
 Equus caballus

Organism

Organism UniProt Comment Textmining
Equus caballus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
serum
-
 Equus caballus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
butyrylthiocholine + H2O
-
 Equus caballus butyrate + thiocholine
-
 ?

Synonyms

Synonyms Comment Organism
BChE
-
 Equus caballus
butyrylcholinesterase
-
 Equus caballus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00023
-
 1,2-dimethyl-beta-carbolin-2-ium iodide pH and temperature not specified in the publication Equus caballus
0.000637
-
 2-ethyl-1-methyl-beta-carbolin-2-ium iodide pH and temperature not specified in the publication Equus caballus
0.09
-
 Harmane pH and temperature not specified in the publication Equus caballus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00023
-
 pH and temperature not specified in the publication Equus caballus 1,2-dimethyl-beta-carbolin-2-ium iodide
0.000637
-
 pH and temperature not specified in the publication Equus caballus 2-ethyl-1-methyl-beta-carbolin-2-ium iodide
0.0012
-
 pH and temperature not specified in the publication Equus caballus 6-methoxy-1,2-dimethyl-9H-beta-carbolin-2-ium iodide
0.0037
-
 pH and temperature not specified in the publication Equus caballus physostigmine
0.0132
-
 pH and temperature not specified in the publication Equus caballus 6-chloro-2-methyl-9H-beta-carbolin-2-ium iodide
0.09
-
 pH and temperature not specified in the publication Equus caballus Harmane