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Literature summary for 3.1.1.8 extracted from

  • Vinsova, J.; Kratky, M.; Komloova, M.; Dadapeer, E.; Stepankova, S.; Vorcakova, K.; Stolarikova, J.
    Diethyl 2-(phenylcarbamoyl)phenyl phosphorothioates: synthesis, antimycobacterial activity and cholinesterase inhibition (2014), Molecules, 19, 7152-7168.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
galanthamine
-
Equus caballus
O-(4-bromo-2-[[3-(trifluoromethyl)phenyl]carbamoyl]phenyl) O,O-diethyl phosphorothioate
-
Equus caballus
O-(4-bromo-2-[[4-(trifluoromethyl)phenyl]carbamoyl]phenyl) O,O-diethyl phosphorothioate least effective inhibitor Equus caballus
O-(4-chloro-2-[[3-(trifluoromethyl)phenyl]carbamoyl]phenyl) O,O-diethyl phosphorothioate
-
Equus caballus
O-(4-chloro-2-[[4-(trifluoromethyl)phenyl]carbamoyl]phenyl) O,O-diethyl phosphorothioate
-
Equus caballus
O-(5-chloro-2-[[3-(trifluoromethyl)phenyl]carbamoyl]phenyl) O,O-diethyl phosphorothioate
-
Equus caballus
O-(5-chloro-2-[[4-(trifluoromethyl)phenyl]carbamoyl]phenyl) O,O-diethyl phosphorothioate
-
Equus caballus
O-[2-[(3-bromophenyl)carbamoyl]-4-chlorophenyl] O,O-diethyl phosphorothioate
-
Equus caballus
O-[2-[(3-bromophenyl)carbamoyl]-5-chlorophenyl] O,O-diethyl phosphorothioate
-
Equus caballus
O-[2-[(4-bromophenyl)carbamoyl]-4-chlorophenyl] O,O-diethyl phosphorothioate
-
Equus caballus
O-[2-[(4-bromophenyl)carbamoyl]-5-chlorophenyl] O,O-diethyl phosphorothioate
-
Equus caballus
O-[4-bromo-2-[(3,4-dichlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
-
Equus caballus
O-[4-bromo-2-[(3-bromophenyl)carbamoyl]phenyl] diethyl phosphate
-
Equus caballus
O-[4-bromo-2-[(3-chlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
-
Equus caballus
O-[4-bromo-2-[(3-fluorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
-
Equus caballus
O-[4-bromo-2-[(4-bromophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
-
Equus caballus
O-[4-bromo-2-[(4-chlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
-
Equus caballus
O-[4-bromo-2-[(4-fluorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
-
Equus caballus
O-[4-chloro-2-[(3,4-dichlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
-
Equus caballus
O-[4-chloro-2-[(3-chlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
-
Equus caballus
O-[4-chloro-2-[(3-fluorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
-
Equus caballus
O-[4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
-
Equus caballus
O-[4-chloro-2-[(4-fluorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
-
Equus caballus
O-[5-chloro-2-[(3,4-dichlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
-
Equus caballus
O-[5-chloro-2-[(3-chlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
-
Equus caballus
O-[5-chloro-2-[(3-fluorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate second best inhibitor Equus caballus
O-[5-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
-
Equus caballus
O-[5-chloro-2-[(4-fluorophenyl)-carbamoyl]phenyl] O,O-diethyl phosphorothioate most efficient inhibitor Equus caballus
rivastigmine
-
Equus caballus

Organism

Organism UniProt Comment Textmining
Equus caballus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
serum
-
Equus caballus
-

Synonyms

Synonyms Comment Organism
BChE
-
Equus caballus
butyrylcholinesterase
-
Equus caballus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00796
-
pH and temperature not specified in the publication Equus caballus galanthamine
0.00867
-
pH and temperature not specified in the publication Equus caballus O-[5-chloro-2-[(4-fluorophenyl)-carbamoyl]phenyl] O,O-diethyl phosphorothioate
0.00868
-
pH and temperature not specified in the publication Equus caballus O-[5-chloro-2-[(3-fluorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
0.0118
-
pH and temperature not specified in the publication Equus caballus O-[4-chloro-2-[(3-fluorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
0.0122
-
pH and temperature not specified in the publication Equus caballus O-[4-bromo-2-[(3-fluorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
0.0125
-
pH and temperature not specified in the publication Equus caballus O-[5-chloro-2-[(3-chlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
0.0126
-
pH and temperature not specified in the publication Equus caballus O-[4-bromo-2-[(4-fluorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
0.0127
-
pH and temperature not specified in the publication Equus caballus O-[4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
0.0135
-
pH and temperature not specified in the publication Equus caballus O-[4-bromo-2-[(4-chlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
0.0138
-
pH and temperature not specified in the publication Equus caballus O-[5-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
0.0139
-
pH and temperature not specified in the publication Equus caballus O-[4-bromo-2-[(3-chlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
0.0147
-
pH and temperature not specified in the publication Equus caballus O-[5-chloro-2-[(3,4-dichlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
0.0148
-
pH and temperature not specified in the publication Equus caballus O-[4-chloro-2-[(3-chlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
0.0149
-
pH and temperature not specified in the publication Equus caballus O-[4-chloro-2-[(4-fluorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
0.0149
-
pH and temperature not specified in the publication Equus caballus O-[2-[(3-bromophenyl)carbamoyl]-5-chlorophenyl] O,O-diethyl phosphorothioate
0.015
-
pH and temperature not specified in the publication Equus caballus O-(5-chloro-2-[[3-(trifluoromethyl)phenyl]carbamoyl]phenyl) O,O-diethyl phosphorothioate
0.0151
-
pH and temperature not specified in the publication Equus caballus O-[2-[(3-bromophenyl)carbamoyl]-4-chlorophenyl] O,O-diethyl phosphorothioate
0.0151
-
pH and temperature not specified in the publication Equus caballus O-[2-[(4-bromophenyl)carbamoyl]-4-chlorophenyl] O,O-diethyl phosphorothioate
0.0156
-
pH and temperature not specified in the publication Equus caballus O-(4-chloro-2-[[4-(trifluoromethyl)phenyl]carbamoyl]phenyl) O,O-diethyl phosphorothioate
0.0164
-
pH and temperature not specified in the publication Equus caballus O-[2-[(4-bromophenyl)carbamoyl]-5-chlorophenyl] O,O-diethyl phosphorothioate
0.0174
-
pH and temperature not specified in the publication Equus caballus O-[4-chloro-2-[(3,4-dichlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
0.0183
-
pH and temperature not specified in the publication Equus caballus O-(5-chloro-2-[[4-(trifluoromethyl)phenyl]carbamoyl]phenyl) O,O-diethyl phosphorothioate
0.0188
-
pH and temperature not specified in the publication Equus caballus O-[4-bromo-2-[(3,4-dichlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
0.0189
-
pH and temperature not specified in the publication Equus caballus O-[4-bromo-2-[(4-bromophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
0.0199
-
pH and temperature not specified in the publication Equus caballus O-(4-chloro-2-[[3-(trifluoromethyl)phenyl]carbamoyl]phenyl) O,O-diethyl phosphorothioate
0.01995
-
pH and temperature not specified in the publication Equus caballus rivastigmine
0.02
-
pH and temperature not specified in the publication Equus caballus O-[4-bromo-2-[(3-bromophenyl)carbamoyl]phenyl] diethyl phosphate
0.02
-
pH and temperature not specified in the publication Equus caballus O-(4-bromo-2-[[3-(trifluoromethyl)phenyl]carbamoyl]phenyl) O,O-diethyl phosphorothioate
0.0202
-
pH and temperature not specified in the publication Equus caballus O-(4-bromo-2-[[4-(trifluoromethyl)phenyl]carbamoyl]phenyl) O,O-diethyl phosphorothioate