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Literature summary for 3.1.1.8 extracted from
- Neuroprotective effect of seaweeds inhabiting South Indian coastal area (Hare Island, Gulf of Mannar Marine Biosphere Reserve): Cholinesterase inhibitory effect of Hypnea valentiae and Ulva reticulata (2010), Neurosci. Lett., 468, 216-219.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| donepezil | standard drug against Alzheimer's disease, mixed type inhibition, Ki: 1.41 mg/ml | Oreochromis niloticus |  |
| methanolic exrtact of Dictyota dichotoma | methanolic extract, noncompetitive type inhibition, , Ki: 0.9 mg/ml | Oreochromis niloticus | |
| methanolic exrtact of Enteromorpha intestinalis | methanolic extract, mixed-type inhibition, Ki: 0.95 mg/ml | Oreochromis niloticus | |
| methanolic exrtact of Hypnea valentine | methanolic extract, mixed-type inhibition, Ki: 0.75 mg/ml | Oreochromis niloticus | |
| methanolic exrtact of Ulva reticulate | methanolic extract, mixed-type inhibition, Ki: 0.6 mg/ml | Oreochromis niloticus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 2.38 | - |
butyrylthiocholine iodide | with methanolic extract of Hypnea valentine (1.3-6.5 mg/ml), Vmax: 190.9 nmole/min/mg protein | Oreochromis niloticus | |
| 2.63 | - |
butyrylthiocholine iodide | with methanolic extract of Ulva reticulate (2-10 mg/ml), Vmax: 182.6 nmole/min/mg protein | Oreochromis niloticus | |
| 2.77 | - |
butyrylthiocholine iodide | with methanolic extract of Dictyota dichotoma (1.3 - 6.5 mg/ml), Vmax: 232.8 nmole/min/mg protein | Oreochromis niloticus | |
| 2.83 | - |
butyrylthiocholine iodide | with inhibitor donepezil (0.4-4.15 mg/ml), Vmax: 183.6 nmole/min/mg protein | Oreochromis niloticus | |
| 2.87 | - |
butyrylthiocholine iodide | with methanolic extract of Enteromorpha intestinalis (1.4 - 7 mg/ml), Vmax: 192.8 nmole/min/mg protein | Oreochromis niloticus | |
| 3.9 | - |
butyrylthiocholine iodide | Vmax: 245.6 nmole/min/mg protein | Oreochromis niloticus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Oreochromis niloticus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| butyrylthiocholine iodide + H2O | - |
Oreochromis niloticus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| BuChE | - |
Oreochromis niloticus |
| butyrylcholinesterase | - |
Oreochromis niloticus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| additional information | - |
assay at room temperature | Oreochromis niloticus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Oreochromis niloticus |
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Release 2023.1 (January 2023)
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