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Literature summary for 3.1.1.8 extracted from

  • Podoly, E.; Bruck, T.; Diamant, S.; Melamed-Book, N.; Weiss, A.; Huang, Y.; Livnah, O.; Langermann, S.; Wilgus, H.; Soreq, H.
    Human recombinant butyrylcholinesterase purified from the milk of transgenic goats interacts with beta-amyloid fibrils and suppresses their formation in vitro (2008), Neurodegener. Dis., 5, 232-236.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of the recombinant human BChE in the milk of transgenic goats Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular serum enzyme Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme participates in neurogenesis and neurite growth in neurons and glia, and prolongates the ThT lag time and reduces the apparent rate of beta-amyloid-fibril formation compared to beta-amyloid alone ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant human BChE from the milk of transgenic goats to homogeneity Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain in neurons and glia, in Alzheimer’s disease, brain butyrylcholinesterase co-localizes with beta-amyloid fibrils Homo sapiens
-
heart
-
Homo sapiens
-
liver
-
Homo sapiens
-
lung
-
Homo sapiens
-
muscle
-
Homo sapiens
-
serum
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme participates in neurogenesis and neurite growth in neurons and glia, and prolongates the ThT lag time and reduces the apparent rate of beta-amyloid-fibril formation compared to beta-amyloid alone Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
BChE
-
Homo sapiens
butyrylcholinesterase
-
Homo sapiens